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KAKEN_17H04089seika.pdf
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Download
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:229.3 KB
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| Last updated |
:Mar 5, 2021 |
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Total downloads since Mar 5, 2021 : 485
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| Title |
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腸内代謝産物によるT細胞非依存的IgA産生誘導機構の解明
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チョウナイ タイシャ サンブツ ニ ヨル Tサイボウ ヒイゾンテキ IgA サンセイ ユウドウ キコウ ノ カイメイ
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Chōnai taisha sanbutsu ni yoru Tsaibō hiizonteki IgA sansei yūdō kikō no kaimei
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Elucidation of T-independent IgA class switch machinery
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長谷, 耕二
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ハセ, コウジ
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Hase, Kōji
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慶應義塾大学・薬学部 (芝共立) ・教授
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Research team head
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科研費研究者番号 : 20359714
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2020
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科学研究費補助金研究成果報告書
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2019
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腸管の粘膜固有層では、ヘルパーT細胞が介在することなくIgAへのクラススイッチが誘導されるT細胞非依存的IgAクラススイッチと呼ばれる仕組みが存在する。本研究では腸内細菌由来の酪酸が、樹状細胞の活性制御を行うことで、T細胞非依存的IgAクラススイッチを促進し、粘膜面のバリア機能を高めることを明らかにした。
Secretory immunoglobulin A, the most abundant antibody isotype in the body, maintains a mutual relationship with commensal bacteria and acts as a primary barrier at the mucosal surface. Colonization by commensal bacteria induces an IgA response, at least partly through a T-cell-independent process. However, the mechanism underlying the commensal-bacteria-induced T-cell-independent IgA response has yet to be fully clarified. Here, we show that commensal-bacteria-derived butyrate promotes T-cell-independent IgA class switching recombination (CSR) in the mouse colon.
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研究種目 : 基盤研究 (B) (一般)
研究期間 : 2017～2019
課題番号 : 17H04089
研究分野 : 免疫学
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