1p19q共欠失を持つグリオーマ57例における予後因子の検討を行ったところ、治療開始時の年齢、手術摘出率、腫瘍最大径、初回補助療法、組織型、MGMTメチル化の有無などの因子と予後との関連性はなく、Grade Ⅲと19p gainが予後不良因子であることが示唆された。 妊娠中あるいは分娩後に発症した脳腫瘍13例においてVEGFR-1/2、EGFR、c-Mycは妊娠におけるいずれの時期でも発現が認められ、性ホルモンレセプター及びHER-2は分娩直後に発現が多く認められた。c-Mycの増幅あるいは発現増加が複数の症例で認められ、妊娠中あるいは分娩後に腫瘍が増大する機序との関連性が示唆された。
First study included 57 patients with codeleted gliomas. No significant difference was observed in the overall survival of the patients with respect to age, degree of resection, maximum tumor diameter,histological subtype, and MGMT promoter methylation status. Gain of chromosome 19p and grade III histology were associated with shorter OS and they might be negative prognostic factors for the patients with gliomas showing total 1p19q loss. Second study included 13 patients with brain tumors manifested or progressed during pregnancy. Expression of VEGFR-1/2, EGFR and c-Myc were observed regardless of the stage of pregnancy. Sex hormone receptors and HER-2 were mainly expressed in the tumors progressed during the postpartum. There was no specific CNAs shared between the pregnancy-associated brain tumors. However, it should be noted that an anaplastic astrocytoma with IDH mutation progressed from the precedent grade 2 tumors showed numerous CNAs including amplification of the c-Myc locus.

研究種目 : 若手研究(B)
研究期間 : 2016～2018
課題番号 : 16K20025
研究分野 : 脳腫瘍