| Item Type |
Article |
| ID |
|
| Preview |
| Image |
|
| Caption |
|
|
| Full text |
KAKEN_16H04731seika.pdf
| Type |
:application/pdf |
Download
|
| Size |
:704.3 KB
|
| Last updated |
:Nov 14, 2022 |
| Downloads |
: 460 |
Total downloads since Nov 14, 2022 : 460
|
|
| Release Date |
|
| Title |
| Title |
深層学習を用いたマウス胚核同定画像解析アルゴリズムの開発
|
| Kana |
シンソウ ガクシュウ オ モチイタ マウスハイ カク ドウテイ ガゾウ カイセキ アルゴリズム ノ カイハツ
|
| Romanization |
Shinsō gakushū o mochiita mausuhai kaku dōtei gazō kaiseki arugorizumu no kaihatsu
|
|
| Other Title |
| Title |
Development of deep learning-based nuclear detection algorithm for mouse embryo
|
| Kana |
|
| Romanization |
|
|
| Creator |
| Name |
舟橋, 啓
 |
| Kana |
フナハシ, アキラ
|
| Romanization |
Funahashi, Akira
|
| Affiliation |
慶應義塾大学・理工学部 (矢上) ・准教授
|
| Affiliation (Translated) |
|
| Role |
Research team head
|
| Link |
科研費研究者番号 : 70324548
|
| Name |
山田, 貴大
|
| Kana |
ヤマダ, タカヒロ
|
| Romanization |
Yamada, Takahiro
|
| Affiliation |
慶應義塾大学・理工学部・助教
|
| Affiliation (Translated) |
|
| Role |
Collaborator
|
| Link |
科研費研究者番号 : 20837736
|
| Name |
徳岡, 雄大
|
| Kana |
トクオカ, ユウタ
|
| Romanization |
Tokuoka, Yūta
|
| Affiliation |
慶應義塾大学・理工学部・博士課程学生
|
| Affiliation (Translated) |
|
| Role |
Collaborator
|
| Link |
|
| Name |
吉見, 祐亮
|
| Kana |
ヨシミ, ユウスケ
|
| Romanization |
Yoshimi, Yūsuke
|
| Affiliation |
慶應義塾大学・理工学部・修士課程学生
|
| Affiliation (Translated) |
|
| Role |
Collaborator
|
| Link |
|
| Name |
大岡, 麻耶
|
| Kana |
オオオカ, マヤ
|
| Romanization |
Ōoka, Maya
|
| Affiliation |
慶應義塾大学・理工学部・修士課程学生
|
| Affiliation (Translated) |
|
| Role |
Collaborator
|
| Link |
|
| Name |
西本, 勝利
|
| Kana |
ニシモト, ショウリ
|
| Romanization |
Nishimoto, Shōri
|
| Affiliation |
慶應義塾大学・理工学部・修士課程学生
|
| Affiliation (Translated) |
|
| Role |
Collaborator
|
| Link |
|
| Name |
本室, 美貴子
|
| Kana |
モトムロ, ミキコ
|
| Romanization |
Motomuro, Mikiko
|
| Affiliation |
慶應義塾大学・理工学部・修士課程学生
|
| Affiliation (Translated) |
|
| Role |
Collaborator
|
| Link |
|
| Name |
中谷, 諒
|
| Kana |
ナカタニ, リョウ
|
| Romanization |
Nakatani, Ryō
|
| Affiliation |
慶應義塾大学・理工学部・修士課程学生
|
| Affiliation (Translated) |
|
| Role |
Collaborator
|
| Link |
|
| Name |
山縣, 一夫
|
| Kana |
ヤマガタ, カズオ
|
| Romanization |
Yamagata, Kazuo
|
| Affiliation |
近畿大学・生物理工学部・准教授
|
| Affiliation (Translated) |
|
| Role |
Research team member
|
| Link |
科研費研究者番号 : 10361312
|
| Name |
広井, 賀子
|
| Kana |
ヒロイ, ノリコ
|
| Romanization |
Hiroi, Noriko
|
| Affiliation |
山陽小野田市立山口東京理科大学・薬学部・教授
|
| Affiliation (Translated) |
|
| Role |
Research team member
|
| Link |
科研費研究者番号 : 20548408
|
|
| Edition |
|
| Place |
|
| Publisher |
|
| Date |
| Issued (from:yyyy) |
2020
|
| Issued (to:yyyy) |
|
| Created (yyyy-mm-dd) |
|
| Updated (yyyy-mm-dd) |
|
| Captured (yyyy-mm-dd) |
|
|
| Physical description |
|
| Source Title |
| Name |
科学研究費補助金研究成果報告書
|
| Name (Translated) |
|
| Volume |
|
| Issue |
|
| Year |
2019
|
| Month |
|
| Start page |
|
| End page |
|
|
| ISSN |
|
| ISBN |
|
| DOI |
|
| URI |
|
| JaLCDOI |
|
| NII Article ID |
|
| Ichushi ID |
|
| Other ID |
|
| Doctoral dissertation |
| Dissertation Number |
|
| Date of granted |
|
| Degree name |
|
| Degree grantor |
|
|
| Abstract |
深層学習 (Deep Learning) を利用することで、今まで困難だったマウス胚発生の4次元蛍光顕微鏡画像から核同定を行う画像処理アルゴリズムを開発した。既存のマウス胚発生における細胞動態の解析では、4次元顕微鏡画像に対しては16細胞期以降の核同定の精度は非常に低くなってしまうといった問題点があった。本研究課題では、近年画像解析にて強力な手法として注目を集めている深層学習を用いた核同定アルゴリズムを開発し、50細胞期までの正確な核同定を行い、胚の質を評価し得る定量的な指標の獲得を行った。
Using deep learning, we developed an image processing algorithm to identify nuclei from the 4-dimensional fluorescence microscopic images of mouse embryo development. The existing analysis of cell dynamics in mouse embryogenesis has a problem that the accuracy of nuclear identification after 16 cell stages is very low for the 4D microscopy images. In this research, we developed a nuclear identification algorithm using deep learning, which has recently attracted attention as a powerful technique in image analysis. Our algorithm performed accurate nuclear identification up to the 50 cell stage to obtain quantitative criteria that can evaluate the quality of embryos.
|
|
| Table of contents |
|
| Keyword |
|
| NDC |
|
| Note |
研究種目 : 基盤研究 (B) (一般)
研究期間 : 2016～2019
課題番号 : 16H04731
研究分野 : 定量生物学
|
|
| Language |
|
| Type of resource |
|
| Genre |
|
| Text version |
|
| Related DOI |
|
| Access conditions |
|
| Last modified date |
|
| Creation date |
|
| Registerd by |
|
| History |
| Mar 5, 2021 | | インデックス を変更 |
| Nov 14, 2022 | | Creator Name,Creator Kana,Creator Romanization,Creator Affiliation,Creator Affiliation (Translated),Creator Role,Creator Link,Creator 著者ID,Abstract 内容,Note 注記 を変更 |
|
|
| Index |
|
| Related to |
|
