| Item Type |
Article |
| ID |
|
| Preview |
| Image |
|
| Caption |
|
|
| Full text |
KAKEN_15K19579seika.pdf
| Type |
:application/pdf |
Download
|
| Size |
:271.2 KB
|
| Last updated |
:Aug 2, 2019 |
| Downloads |
: 386 |
Total downloads since Aug 2, 2019 : 386
|
|
| Release Date |
|
| Title |
| Title |
SLEの免疫学的分類による治療最適化に関する研究
|
| Kana |
SLE ノ メンエキガクテキ ブンルイ ニ ヨル チリョウ サイテキカ ニ カンスル ケンキュウ
|
| Romanization |
SLE no menekigakuteki bunrui ni yoru chiryō saitekika ni kansuru kenkyū
|
|
| Other Title |
| Title |
Optimization of the treatment of systemic lupus erythematosus by immunological classifications
|
| Kana |
|
| Romanization |
|
|
| Creator |
| Name |
菊池, 潤
 |
| Kana |
キクチ, ジュン
|
| Romanization |
Kikuchi, Jun
|
| Affiliation |
慶應義塾大学・医学部(信濃町)・助教
|
| Affiliation (Translated) |
|
| Role |
Research team head
|
| Link |
科研費研究者番号 : 20570881
|
|
| Edition |
|
| Place |
|
| Publisher |
|
| Date |
| Issued (from:yyyy) |
2018
|
| Issued (to:yyyy) |
|
| Created (yyyy-mm-dd) |
|
| Updated (yyyy-mm-dd) |
|
| Captured (yyyy-mm-dd) |
|
|
| Physical description |
|
| Source Title |
| Name |
科学研究費補助金研究成果報告書
|
| Name (Translated) |
|
| Volume |
|
| Issue |
|
| Year |
2017
|
| Month |
|
| Start page |
|
| End page |
|
|
| ISSN |
|
| ISBN |
|
| DOI |
|
| URI |
|
| JaLCDOI |
|
| NII Article ID |
|
| Ichushi ID |
|
| Other ID |
|
| Doctoral dissertation |
| Dissertation Number |
|
| Date of granted |
|
| Degree name |
|
| Degree grantor |
|
|
| Abstract |
本研究ではヒトSLEの病態解析と個別化医療のためのアルゴリズム確立を追求した。細胞表面分子の網羅的解析からMilk Fat Globule Epidermal growth factor 8 (MFG-E8)に着目した。末梢血中のMFG-E8陽性単球数は疾患活動性と相関した。皮膚, 筋骨格病変, 白血球減少を有する患者で高値であり, 障害臓器での特徴を有する可能性を報告した。また, CD8T細胞亜分画は疾患活動性と相関し, 各障害臓器との関連を示した。以上より, 末梢血免疫細胞および血清蛋白を指標として, 障害臓器および免疫学的アプローチから層別化することの実現可能性が示唆された。
The aim of this study was to analyze the pathogenesis of SLE leading to optimization of the management. We selected the molecule, Milk Fat Globule Epidermal growth factor 8 (MFG-E8), with comprehensive protein analysis. We reported that MFG-E8 positive peripheral monocytes correlated with the disease activity, and were higher in patients with skin, musculoskeletal and lymphocytopenia. In addition, the subpopulations of peripheral CD8 positive T cells correlated with disease activity and were associated with some clinical organ characteristics. Our study indicated the possibility that immunological approach with serum proteins and peripheral immune cells may enable us to classify and implement personalized management.
|
|
| Table of contents |
|
| Keyword |
|
| NDC |
|
| Note |
研究種目 : 若手研究(B)
研究期間 : 2015～2017
課題番号 : 15K19579
研究分野 : リウマチ・膠原病
|
|
| Language |
|
| Type of resource |
|
| Genre |
|
| Text version |
|
| Related DOI |
|
| Access conditions |
|
| Last modified date |
|
| Creation date |
|
| Registerd by |
|
| History |
| Nov 12, 2018 | | インデックス を変更 |
| Aug 2, 2019 | | 著者,抄録 内容,注記 を変更 |
|
|
| Index |
|
| Related to |
|
