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KAKEN_15K10728seika.pdf
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:Nov 12, 2018 |
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EMT関連遺伝子を標的とした新規分子標的薬の開発
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EMT カンレン イデンシ オ ヒョウテキ ト シタ シンキ ブンシ ヒョウテキヤク ノ カイハツ
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EMT kanren idenshi o hyōteki to shita shinki bunshi hyōtekiyaku no kaihatsu
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Development of new molecular targeted drugs targeting EMT-related genes in endometrial cancer
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片岡, 史夫
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カタオカ, フミオ
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Kataoka, Fumio
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慶應義塾大学・医学部(信濃町)・助教
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Research team head
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科研費研究者番号 : 40306824
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田中, 英男
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タナカ, ヒデオ
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Tanaka, Hideo
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Research team member
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2018
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科学研究費補助金研究成果報告書
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2017
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EMT関連遺伝子群でクラスタリングを行ったところ, 癌肉腫は子宮体癌よりも肉腫と類似性を認めた。また, 癌肉腫の癌部および肉腫部でEMT関連遺伝子群の発現を比較したところ, 肉腫部でZeb, Twist, SnailなどのEMT誘導転写因子およびそのパスウェイに関与する遺伝子群の高発現を確認した。
癌肉腫の癌部においては, 子宮体癌と比較してリン酸化SMAD2/3が有意に高発現を示した。一方, 癌肉腫の癌部および肉腫部におけるリン酸化SMAD2/3の発現には有意差は認めなかった。子宮体部癌肉腫で活性化されているTGFβシグナル伝達系のEMTへの寄与が示唆された。
Uterine carcinosarcoma is reported to undergo epithelial to mesenchymal transition (EMT). The gene expression profiles of uterine carcinosarcoma, endometrial cancer, and uterine sarcoma were compared and evaluated the role of EMT and chromosomal aberrations in uterine carcinosarcoma tumor formation. The expression of 39 EMT-related genes and evaluated TGF-beta signaling by phospho-SMAD2/3 (p-SMAD2/3) staining were examined. Acquired markers of EMT were upregulated in uterine carcinosarcoma.
Based on the expression profile, uterine carcinosarcoma resembles uterine sarcoma rather than endometrial cancer. Immunohistochemistry showed that carcinomatous region of uterine carcinosarcoma have higher expression of p-SMAD2/3 than endometrial cancer. TGF-beta signaling is activated in uterine carcinosarcoma, which suggest that this may contribute to high expression of TGF-beta and thereby EMT phenotype of uterine carcinosarcoma.
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研究種目 : 基盤研究(C)(一般)
研究期間 : 2015～2017
課題番号 : 15K10728
研究分野 : 婦人科腫瘍学
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