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KAKEN_15K09061seika.pdf
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Download
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:219.4 KB
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:Nov 12, 2018 |
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Total downloads since Nov 12, 2018 : 359
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| Title |
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内視鏡と腹腔鏡による新しい胃癌低侵襲手術の確立とその妥当性の検討
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ナイシキョウ ト フククウキョウ ニ ヨル アタラシイ イガン テイシンシュウ シュジュツ ノ カクリツ ト ソノ ダトウセイ ノ ケントウ
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Naishikyō to fukukūkyō ni yoru atarashii igan teishinshū shujutsu no kakuritsu to sono datōsei no kentō
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Development of novel minimally-invasive surgery for gastric cancer using endoscopy and laparoscopy
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後藤, 修
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ゴトウ, オサム
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Goto, Osamu
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| Affiliation |
慶應義塾大学・医学部(信濃町)・講師
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Research team head
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科研費研究者番号 : 00589658
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竹内, 裕也
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タケウチ, ヒロヤ
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Takeuchi, Hiroya
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浜松医科大学・医学部・教授
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Research team member
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科研費研究者番号 : 20265838
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佐谷, 秀行
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サヤ, ヒデユキ
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Saya, Hideyuki
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Research team member
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大島, 正伸
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オオシマ, マサノブ
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Oshima, Masanobu
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野原, 京子
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ノハラ, キョウコ
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Nohara, Kyoko
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Research team member
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2018
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科学研究費補助金研究成果報告書
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2017
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| Abstract |
非穿孔式内視鏡的胃壁内反切除術(NEWS)+センチネルリンパ節ナビゲーション手術(SNND)の妥当性を理論的に証明するために以下の研究を行った。①NEWS+SNNS計11例における治療成績を解析した。全例において手技を完遂, 平均観察期間2.0年において全例無再発生存中であった。②内視鏡治療直後の早期胃癌検体表面を用いて捺印細胞診を行った結果, 癌幹細胞を含む癌細胞が接触により容易に遊離することが明らかとなった。③生体ブタを用いて内視鏡治療前後の胃リンパ流変化を検討した結果, 部位によってはリンパ流が改変される可能性があることが示唆された。④胃癌モデルマウスでは医原性性腹膜播種を認めなかった。
To investigate the usefulness of nonexposed endoscopic wall-inversion surgery (NEWS) with sentinel node navigation surgery (SNNS), the following studies were conducted. 1. In 11 cases of NEWS+SNNS, the procedure was completed in all cases, and 2 years' survival was quite favorable without recurrence. 2. Stump cytology on the surface of resected early gastric cancers revealed that cancerous cells were easily detached from the surface. 3. An in-vivo porcine study showed that the lymphatic flows of the stomach could be changeable after endoscopic resection according to the location of the lesion. 4. An animal study using gastric cancer model mice failed to demonstrate iatrogenic cancer cell seeding by opening the stomach with spontanesously developed gastric cancer.
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研究種目 : 基盤研究(C)(一般)
研究期間 : 2015～2017
課題番号 : 15K09061
研究分野 : 医師薬学
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