In this paper, the phenomena of social stigma, particularly the interaction between physically disabled persons and the nondisabled, were discussed in terms of experimental studies. The, main point of the discussion is that stigma is seen as a product of definitional processes arising out of social interaction, and not as an attribute that people automatically have when they acquire a trait or quality that may be discrediting. That is, stigmatization is regarded as a process in which particular social meanings come to be attached to categories of behavior and to individuals. The following things were found through the review of experimental studies which were conducted in different situations. (1) The reactions of the normals to the stigmatized are ambivalent. They can be either hostile and rejecting or sympathetic and helpful, depending on the circumstances of contact. (2) Physically disabled persons not only have the problems of coping with their physical handicaps, but are likely to experience social handicaps as well. One social handicap disabled persons face is that, in initial encounters, nondisabled persons tend to avoid social interaction with them. In this situation, one technique available to the disabled person is voluntarily to mention his handicap.