To　investigate　the　relationship　between　oxidative　stress　and　the　development　of　diabetic　angiopathy,　194　type　2　diabetic　subjects　were　enrolled,　and　divided　into　three　groups;　Group　I　without　diabetic　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　angiopathy,　Group　II　with　microangiopathy.　and　Group　III　with　macroangiopathy.　We　detemined　the　ratlo　of　oxidized　albumin　(ROA),　and　other　oxidative　stress　markers,　inflammation　markers,　PAI-1　and　some　growth　factors.　We　then　analyzed　the　relationshipbetween　the　levels　of　oxidative　stress　markers　and　the　other　markers.　It　was　found　that　the　ROA　and　SOD　were　increased　relative　to　the　control　group　in　all　the　groups.　A　negative　correlation　between　the　ROA　and　PDGF　and　positive　correlations　between　both　glutathione　peroxidase　and　lipid　peroxide　and　PAI-1　were　found　in　Group　I.　In　Group　II,　positive　correlations　were　found　between　catalase　and　CRP,　and　lipid　peroxide　and　PAI-1,　and　a　negative　correlation　was　found　between　the　ROA　and　PDGF.　In　Group　m,　a　positive　correLation　between　SOD　and　PAI-1　was　observed.　These　findings　suggest　that　the　onset　of　microangiopathy　in　diabetes　mellitus　rnay　be　attributable　to　the　effect　of　oxidative　stresses　on　PDGF,　PAI-1　　and　CRP,　and　that　the　onset　of　rnacroangiopathy　may　be　attributable　to　the　effect　of　oxidative　stresses　on　PAI-1.

原著