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AN00069296-20030900-0071.pdf
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Title |
Title |
ビスホスフォネートが骨粗鬆症患者の腰背痛におよぼす効果
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Kana |
ビスホスフォネート ガ コツソショウショウ カンジャ ノ ヨウハイツウ ニ オヨボス コウカ
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Romanization |
bisuhosufoneto ga kotsusoshosho kanja no yohaitsu ni oyobosu koka
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Other Title |
Title |
Efficacy of treatment with bisphosphonales for back pain in patients with osteoporosis
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Creator |
Name |
岩本, 潤
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Kana |
イワモト, ジュン
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Romanization |
Iwamoto, Jun
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Affiliation |
慶應義塾大学医学部スポーツクリニック
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Affiliation (Translated) |
Department of Sports Medicine, School of Medicine, Keio University
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Name |
竹田, 毅
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Kana |
タケダ, ツヨシ
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Romanization |
Takeda, Tsuyoshi
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Affiliation |
慶應義塾大学医学部スポーツクリニック
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Affiliation (Translated) |
Department of Sports Medicine, School of Medicine, Keio University
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Name |
慶應医学会
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Kana |
ケイオウ イガッカイ
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Romanization |
Keio igakkai
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Issued (from:yyyy) |
2003
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Physical description |
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Source Title |
Name |
慶應医学
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Name (Translated) |
Journal of the Keio Medical Society
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Volume |
80
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Issue |
3
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Year |
2003
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Month |
9
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Start page |
71
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End page |
76
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Abstract |
In Japan, three types of bisphosphonates, such as etidronate, alendronate, and risedronate, are available in the treatment of osteoporosis. The efficacy of these bisphosphonates for increasing bone mineral density (BMD) and preventing osteoporotic fractures in patients with osteoporosis has been established : etidro nate increases lumbar BMD and prevents incident vertebral fractures, while alendronate and risedronate increase lumbar and femoral neck BMD and prevent incident vertebral fractures and hip fractures. In addition, it has been reported that all of these bisphosphonates have the potential to prevent or relieve back pain in patients with spinal osteoporosis. The mechanism for the prevention or reduction in back pain in patients with osteoporosis by treatment with bisphosphonates remains uncertain, However, available evidente suggests that the prevention of deterioration of bone architecture or the reductions in bone resorption and/or production of interleukins and prostaglandins may contribute to the reduction in back pain in patients with spinal osteoporosis. Bisphosphonates may be useful agents to prevent disability in elderly osteoporotic patients by relieving osteoporosis-related back pain as well as preventing osteoporotic fractures. The aim of osteoporosis treatment should be to prevent or relieve back pain as well as to prevent osteoporotic fractures, subsequently improving quality of life (QOL).
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