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AN00069296-20030601-0111.pdf
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Title |
Title |
マクロファージ由来の nitric oxide による肝細胞酸化的DNA傷害の検討
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Kana |
マクロファージ ユライ ノ nitric oxide ニ ヨル カン サイボウ サンカテキ DNA ショウガイ ノ ケントウ
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Romanization |
makurofaji yurai no nitric oxide ni yoru kan saibo sankateki DNA shogai no kento
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Creator |
Name |
渡部, 直行
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Kana |
ワタナベ, ナオユキ
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Romanization |
Watanabe, Naoyuki
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Affiliation |
慶應義塾大学医学部内科学教室
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Author
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Name |
石井, 裕正
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Kana |
イシイ, ヒロマサ
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Romanization |
Ishii, Hiromasa
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Thesis advisor
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Name |
慶應医学会
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Kana |
ケイオウ イガッカイ
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Romanization |
Keio igakkai
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Date |
Issued (from:yyyy) |
2003
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Issued (to:yyyy) |
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Created (yyyy-mm-dd) |
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Physical description |
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Source Title |
Name |
慶應医学
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Name (Translated) |
Journal of the Keio Medical Society
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Volume |
80
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Issue |
2
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Year |
2003
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Month |
6
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Start page |
T111
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End page |
T122
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Table of contents |
材料および方法
1.細胞の単離と培養法
2.iNOSおよびnitrotyrosineの二重免疫蛍光法
3.培養液中のnitriteとnitrateの濃度
4.8-hydroxy-deoxyguanosine(8-OH-dG)/deoxy guanosine(dG)の測定
5.単鎖DNAの検出
6.統計
結果
1.肝細胞と脾マクロファージの共培養後のiNOSおよび nitrontyrosine の局在
2.培養液中の8時間後のnitriteとnitrateの濃度
3.肝細胞DNAの8-OH-dG/dG測定法
4.肝細胞DNAの8-OH-dG/dG測定値
5.肝細胞の単鎖DNA(AO染色)
6.SIN-1やONOO 投与の肝細胞DNAの8-OH-dG/dGに対する影響
7.SIN-1やONOO 投与の肝細胞の単鎖DNA出現比率に与える影響
考案
総括
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Keyword |
8-hydroxy-deoxyguanosine (8-OH-dG)
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