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KAKEN_26221005seika.pdf
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Download
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:194.7 KB
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:Apr 11, 2024 |
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Total downloads since Apr 11, 2024 : 356
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がん免疫病態の個体差の解明とその制御による個別化がん治療の開発
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| Kana |
ガン メンエキ ビョウタイ ノ コタイサ ノ カイメイ ト ソノ セイギョ ニ ヨル コベツカ ガン チリョウ ノ カイハツ
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Gan men'eki byōtai no kotaisa no kaimei to sono seigyo ni yoru kobetsuka gan chiryō no kaihatsu
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Investigation of differential immune status among cancer patients and development of personalized cancer therapy by combining immunomodulation
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河上, 裕
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カワカミ, ユタカ
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Kawakami, Yutaka
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慶應義塾大学・医学部 (信濃町)・教授
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Research team head
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科研費研究者番号 : 50161287
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谷口, 智憲
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ヤグチ, トモノリ
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Yaguchi, Tomonori
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Collaborator
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大多, 茂樹
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オオタ, シゲキ
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Ōta, Shigeki
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Collaborator
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塚本, 信夫
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ツカモト, ノブオ
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Tsukamoto, Nobuo
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Collaborator
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2019
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科学研究費補助金研究成果報告書
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2018
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がんに対する免疫の状態には個人差があり、免疫療法も含めて広くがん治療の効果に関係するが、その原因や重要性は分かっていなかった。本研究では各種新技術 (遺伝子・免疫・腸内細菌解析など) を駆使して、各種がんの免疫サブタイプを明らかにした。同時に新しく作製したサブタイプに応じたマウス腫瘍やヒト化マウスモデルを用いて、抗腫瘍免疫を増強する薬物候補を見いだした。本研究成果は腫瘍免疫学の進歩に加えて、効果の高い複合免疫療法の開発に役立つ。
Immune status varies among cancer patients and is correlated with responses to various cancer therapies including immunotherapy. However its mechanisms and outcome have not been understood well. In this study, we revealed immunological subtypes of various human cancers using a variety of new technologies such as comprehensive genetic, immunological, and microbial analyses. In addition, we identified various chemicals and antibodies capable of augmenting anti-tumor immunity using mouse tumor models and newly developed humanized mice. These results contribute not only to advance of human tumor immunology, but also to development of effective combination immunotherapy.
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研究種目 : 基盤研究(S)
研究期間 : 2014～2018
課題番号 : 26221005
研究分野 : 腫瘍学, 免疫学
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| Oct 31, 2019 | | インデックス を変更 |
| Apr 11, 2024 | | Creator 著者ID,Creator Name,Creator Kana,Creator Romanization,Creator Affiliation,Creator Affiliation (Translated),Creator Role,Creator Link,Abstract 内容,Note 注記 を変更 |
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