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KAKEN_25462067seika.pdf
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Download
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:283.1 KB
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| Title |
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炎症性腸疾患におけるサーファクタントプロテインD(SP-D)の臨床応用
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| Kana |
エンショウセイ チョウシッカン ニ オケル サーファクタント プロテインD (SP-D) ノ リンショウ オウヨウ
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Enshosei choshikkan ni okeru safakutanto puroteinD (SP-D) no rinsho oyo
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The impact of surfactant protein d on inflammatory bowel disease
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長谷川, 博俊
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ハセガワ, ヒロトシ
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Hasegawa, Hirotoshi
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慶應義塾大学・医学部・准教授
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Research team head
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科研費研究者番号 : 00218455
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鶴田, 雅士
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ツルタ, マサシ
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Tsuruta, Masashi
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慶應義塾大学・医学部・助教
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Research team member
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科研費研究者番号 : 00348666
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矢作, 雅史
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ヤハギ, マサシ
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Yahagi, Masashi
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田島, 佑樹
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タジマ, ユウキ
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Tajima, Yuki
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豊田, 尚潔
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トヨダ, ナオヨシ
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Toyoda, Naoyoshi
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2016
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科学研究費補助金研究成果報告書
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2015
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| Abstract |
サーファクタントプロテインD(SP-D)をコードする SFTPD遺伝に注目し, UCにおけるSP-Dの役割について検討した。大腸炎モデルマウスは対照群に比して血中のSP-D濃度および, 大腸粘膜におけるSP-Dタンパクレベルの上昇を認めた。さらに, SP-Dノックアウトマウスにおいて大腸炎モデルマウスを同様に作成したところ, 通常の大腸炎モデルマウスに比して腸炎が軽減される傾向を認めた。SP-DがUCの発症・重症化に関与していることが示唆され, 治療薬や発症の予防などに応用が期待される。
We focused on surfactant, pulmonary-associated protein D (SFTPD) which encodes surfactant protein D (SP-D) and evaluated the role of SP-D in ulcerative colitis (UC) in this current study. In model mouse with dextran sulfate sodium (DSS) induced colitis, the serum level of SP-D was significantly higher compared with control mouse. In addition, relatively higher level of SP-D protein was observed in mucosa of colon in the mouse with DSS induced colitis mouse. Moreover, the severity of colitis induced by DSS was mitigated in SP-D deficiency mouse compared to wild mouse. Collectively, SP-D would be associated with pathogenesis and progression of UC and could be expected a target for prevention or treatment.
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研究種目 : 基盤研究(C)(一般)
研究期間 : 2013～2015
課題番号 : 25462067
研究分野 : 大腸外科
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