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KAKEN_24659705seika.pdf
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:179.9 KB
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:Jul 26, 2019 |
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Total downloads since Jul 26, 2019 : 361
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| Title |
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低酸素応答をターゲットとした新たな心停止後症候群治療法開発への展望
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テイサンソ オウトウ オ ターゲット ト シタ アラタナ シンテイシゴ ショウコウグン チリョウホウ カイハツ エノ テンボウ
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Teisanso oto o tagetto to shita aratana shinteishigo shokogun chiryoho kaihatsu eno tenbo
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Hypoxic response as a new treatment of Post cardiac arrest syndrome
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南嶋, しづか
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ミナミシマ, シヅカ
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Minamishima, Shizuka
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| Affiliation |
慶應義塾大学・医学部・助教
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Research team head
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科研費研究者番号 : 20622088
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南嶋, 洋司
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ミナミシマ, ヨウジ
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Minamishima, Yoji
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慶應義塾大学・医学部・講師
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Research team member
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科研費研究者番号 : 20593966
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久保, 亜紀子
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クボ, アキコ
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Kubo, Akiko
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慶應義塾大学・医学部・特任講師
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Research team member
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科研費研究者番号 : 50455573
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菱木, 貴子
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ヒシキ, タカコ
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Hishiki, Takako
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慶應義塾大学・医学部・講師
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Research team member
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科研費研究者番号 : 10338022
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末松, 誠
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スエマツ, マコト
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Suematsu, Makoto
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慶應義塾大学・医学部・教授
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Research team member
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科研費研究者番号 : 00206385
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2015
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科学研究費補助金研究成果報告書
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2014
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| Abstract |
我々は一酸化窒素(NO)が心停止(CA)/CPR後の予後を改善することを明らかにした。近年, NOと低酸素に対する低酸素応答を制御する転写因子HIF(hypoxia-inducible factor)には相互作用があることから, HIFの活性化はCPR後の予後を改善するのではないかと考えた。
HIFを活性化させたマウスとその対照群にCA/CPRを試行し, 生存率や心機能, 神経学的機能を比較したが, HIFの活性化はCA/CPR後の予後を改善しなかった。また, CA/CPR後にHIFを活性化させたマウスを用いた実験においても予後改善は認められなかった。
We demonstrated that inhaled Nitric oxide (NO) could improve outcome after successful cardiopulmonary resuscitation (CPR) in mice. It is increasingly recognized that NO production in hypoxia correlate with HIF (hypoxia inducible factor), a transcription factor which regulate hypoxic response. The present study tried to demonstrate whether systemically activating HIF in mice could improve the outcome after CPR.
Although survival rate, neurological and cardiac function ware assessed after cardiac arrest and CPR, HIF activation did not work to improve outcome after CPR.
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研究種目 : 挑戦的萌芽研究
研究期間 : 2012～2014
課題番号 : 24659705
研究分野 : 医歯薬学
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