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KAKEN_24592530seika.pdf
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Download
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:243.0 KB
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婦人科癌転移の特異的糖鎖構造解析と認識糖鎖抗原をターゲットする新規治療抗体の開発
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フジンカガン テンイ ノ トクイテキ トウサ コウゾウ カイセキ ト ニンシキ トウサ コウゲン オ ターゲットスル シンキ チリョウ コウタイ ノ カイハツ
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Fujinkagan teni no tokuiteki tosa kozo kaiseki to ninshiki tosa kogen o tagettosuru shinki chiryo kotai no kaihatsu
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Establishment of an antibody that targets carbohydrate structures specific to metastatic gynaecological malignancies
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鈴木, 淳
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スズキ, アツシ
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Suzuki, Atsushi
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慶應義塾大学・医学部・助教
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Research team head
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科研費研究者番号 : 00255514
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冨永, 英一郎
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トミナガ, エイイチロウ
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Tominaga, Eiichiro
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慶應義塾大学・医学部・講師
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Research team member
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科研費研究者番号 : 80276328
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鈴木, 雅美
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スズキ, マサミ
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Suzuki, Masami
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慶應義塾大学・医学部・研究員
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Research team member
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科研費研究者番号 : 10276321
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2016
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科学研究費補助金研究成果報告書
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2015
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我々が作製したヒトHMMC-1抗体は婦人科癌, 中でも子宮体癌に特異的に抗腫瘍効果を示した。この抗体は子宮体癌の細胞に対しては増殖抑制効果を示し, 異なる転移能を有する細胞では, より高い転移能を持つ細胞に対して, より強い増殖抑制効果を示した。その増殖能の差は細胞周期の影響によらないことを示した。さらにHMMC-1抗体の認識糖鎖抗原を質量分析で解明した。反応タンパクの抗原解析では少なくとも糖タンパク質のCD166およびCD49であることが判明した。今後の新たな治療戦略として, 子宮体癌の中でもCD166発現の上昇を示す症例には, HMMC-1抗体の分子標的治療薬の治療的役割を期待する結果となった。
We established the humanized HMMC-1 antibody which recognizes gynecologic cancers and demonstrates specific anti-tumor activity towards endometrial cancer. In vitro, the antibody demonstrated anti-tumor activity towards endometrial cancer cells with differing lymph node metastasis potential and demonstrated even greater cell proliferation inhibitory effects towards the cell line with greater metastatic potential. Cell cycle analysis demonstrated that this difference in proliferation inhibition was not due to differences in proliferation or cell cycle. In addition, we elucidated the carbohydrate antigen recognized by the HMMC-1 antibody. Using mass spectrometry, we showed that the HMMC-1 antibody recognizes CD 166 and CD 49. Our research thus delineates the future possibility of clinical treatments based on HMMC-1 antibody administration as molecular target therapy towards endometrial cancer cases that demonstrate elevated CD 166 expression levels.
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研究種目 : 基盤研究(C)(一般)
研究期間 : 2012～2015
課題番号 : 24592530
研究分野 : 婦人科腫瘍学
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