25～60歳の非糖尿病者における6年間の縦断的検討で, 男性では耐糖能改善が2名, 不変347名, 悪化41名, 女性では改善は0名, 不変133名, 悪化14名であった。耐糖能悪化と強く相関したベースラインの因子は, 年齢, BMI, 血糖, TG, LDL-C, ALT, γ-GTP, HOMA-R, HMW-ADPNであった。喫煙, 飲酒や運動習慣などとの関連は認められなかった。男性で不変＝0/悪化＝1を従属変数としたステップワイズ多重回帰分析にて, 男性ではベースラインの血糖, HMW-ADPN(F=11.5, r'=-0.165), 年齢の順に採択された(P＜0.0001, R2=0.156)。
In the 6-year longitudinal study on non-diabetic Japanese, aged 25-60 years, glucose tolerance had improved in only 2 subjects, was unchanged in 347 and worsened in 41 in males, and 0, 133 and 14, respectively, in females. Baseline factors correlating significantly with status [No change = 0/Worsened = 1] in males were age, BMI, plasma glucose, TG, LDL-cholesterol, ALT, γ-GTP, HOMA-R, high-molecular-weight (HMW)-adiponectin levels. No correlations were observed with baseline smoking, alcohol consumption or exercise status. Stepwise multiple regression analysis of [No change/Worsened] as a dependent variable revealed that baseline glucose (F=51.2, r'=0.300), HMW-adiponectin (F =11.5, r'=-0.165) and age (F =5.1, r'=0.110) to show significant independent correlations in males (P<0.0001, R2=0.156).
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