LOX-1は, 内皮細胞における変性LDLの受容体である。そこでApoB含有LOX-1リガンド(LAB)と潜在的な動脈硬化所見の関連をみた。40歳代男性では, 米国集団ではLDLCを調整してもLABと頸動脈IMTに有意な正の関連を認めた。しかし日本人集団では関連を認めなかった。平均年齢67歳の日本人集団ではLABと頸動脈IMTに有意な関連を認めたが, LDLCを調整すると有意差は消失した。神戸市の男女 515人では, LDLCを調整してもLABはCAVIと有意な正の関連を示した。通常, IMTよりCAVIのほうがより早期の動脈硬化の指標であるため, LABは日本人の動脈硬化の早期指標として意義がある。
The serum level of LOX-1 ligand containing ApoB (LAB) may reflect atherogenicity better than LDL cholesterol (LDLC) and usual measurement of oxidized LDL. The association between LAB and subclinical atherosclerosis, such as intima-media thickness (IMT) of carotid artery and Cardio Ankle Vascular Index, CAVI, was investigated in community dwellers. In group with a mean age of 45, serum LAB was associated with an increased carotid IMT in US Caucasian men independently of various risk factors (N= 297) ; however, there was no significant relationship between LAB and IMT in Japanese men (N= 310). In other Japanese group with a mean age of 64 (N= 992), serum LAB was associated with an increased carotid IMT only in men with hypercholesterolemia. In 515 healthy Japanese (310 men and 205 women) living in Kobe city, the plasma LAB showed a positive association with the CAVI in men but not in women. LAB may be a useful marker for detecting early stage of atherosclerosis in "healthy" individuals.

研究種目 : 基盤研究(B)
研究期間 : 2011～2014
課題番号 : 23390178
研究分野 : 公衆衛生学