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KAKEN_18K16998seika.pdf
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Download
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:284.6 KB
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| Last updated |
:May 17, 2022 |
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Total downloads since May 17, 2022 : 240
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脱分化脂肪細胞を用いた体幹部皮下脂肪と眼窩脂肪の違いに関する基礎研究
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ダツブンカ シボウ サイボウ オ モチイタ タイカンブ ヒカ シボウ ト ガンカ シボウ ノ チガイ ニ カンスル キソ ケンキュウ
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Datsubunka shibō saibō o mochiita taikanbu hika shibō to ganka shibō no chigai ni kansuru kiso kenkyū
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Basic research on the difference between subcutaneous fat in the trunk and orbital fat using DFAT
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酒井, 成貴
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サカイ, シゲキ
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Sakai, Shigeki
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慶應義塾大学・医学部 (信濃町) ・助教
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Research team head
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科研費研究者番号 : 00464941
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2021
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科学研究費補助金研究成果報告書
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2020
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本研究は眼窩脂肪を含む顔面皮下脂肪と体幹部皮下脂肪の違いに関する基礎研究を行うものである。脂肪細胞に関連してADSCが有名であるが多くはSVFを継代培養してセレクションをかける必要がある。成熟脂肪細胞からの直接培養が可能なDFATではセレクションが必要ない。今回、眼窩の成熟脂肪細胞を正確に反映するDFATの作成に成功した。また体幹部皮下脂肪と眼窩脂肪のマイクロアレイによる解析では有意差はないもののTSHRが眼窩脂肪よりも体幹部皮下脂肪の方に多く発現を認めた。TSHRが高くないことはTSH値が低下しても甲状腺眼症が改善しないことと一致していることが確認できた。
This is a basic study of the difference between subcutaneous fat in the face, including orbital fat, and subcutaneous fat in the trunk. ADSC is well known for adipocytes, requires subculture and selection from stromal vascular cells. DFAT, on the other hand, can be cultured directly from mature adipocytes and does not need to be selected. This time, we succeeded in creating an ORBITAL DFAT that accurately reflects mature adipocytes in orbit. Although there was no significant difference in microarray analysis of trunk subcutaneous fat and orbital fat, TSHR was more frequently expressed in trunk subcutaneous fat than in orbital fat. No correlation was found between TSH levels and thyroid eye disease, confirming that a decrease in TSH was consistent with no improvement in thyroid eye disease.
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研究種目 : 若手研究
研究期間 : 2018～2020
課題番号 : 18K16998
研究分野 : 形成外科
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