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KAKEN_18K06900seika.pdf
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Download
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:259.9 KB
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| Last updated |
:Nov 14, 2022 |
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Total downloads since Nov 14, 2022 : 209
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降圧薬同効薬間の有害事象報告頻度比較分析に基づく妊娠高血圧症治療薬開拓
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コウアツヤク ドウコウヤクカン ノ ユウガイ ジショウ ホウコク ヒンド ヒカク ブンセキ ニ モトズク ニンシン コウケツアツショウ チリョウヤク カイタク
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Kōatsuyaku dōkōyakukan no yūgai jishō hōkoku hindo hikaku bunseki ni motozuku ninshin kōketsuatsushō chiryōyaku kaitaku
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Development of therapeutic agents for preeclampsia based on comparative analysis of adverse event reports between antihypertensive drugs
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西村, 友宏
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ニシムラ, トモヒロ
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Nishimura, Tomohiro
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慶應義塾大学・薬学部 (芝共立) ・准教授
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Research team head
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科研費研究者番号 : 40453518
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野口, 幸希
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ノグチ, サキ
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Noguchi, Saki
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慶應義塾大学・薬学部 (芝共立) ・助教
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Research team member
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科研費研究者番号 : 10803661
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2021
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科学研究費補助金研究成果報告書
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2020
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アンジオテンシンII受容体拮抗薬(ARB)6剤が示す羊水過少の報告頻度は、オルメサルタン等に対し、イルベサルタンが顕著に低いことが示された。妊娠高血圧症候群モデルラットにおいてイルベサルタン投与群はARB非投与群と比較して胎児重量が同等で、オルメサルタンと比較して胎児移行性が低いことが示された。また、ヒト胎盤に発現するOATP2B1により輸送されることが示された。オルメサルタン投与群はARB非投与群と比較して胎児重量が減少した。また、OATP2B1による輸送は観察されなかった。以上より、イルベサルタンはオルメサルタンと比較して、胎児移行性が低く、胎児における毒性も示しにくいことが示唆された。
Reported frequencies of oligohydramnios against 6 drugs of angiotensin II receptor antagonist (ARB) were investigated. The normalized frequency of irbesartan compared that of olmesartan was significantly low. We analyzed the pharmacological effect, placental transfer and fetal toxicity of irbesartan and olmesartan using the preeclampsia model rats. The irbesartan-administered group had the same fetal weight as the ARB-non-administered group and irbesartan had a lower fetal transfer than olmesartan. It was also shown that irbesartan was transported by OATP2B1 which is expressed in human placenta. The olmesartan-treated group had a reduced fetal weight compared to the ARB-non-treated group. In addition, no transport by OATP2B1 was observed. These findings suggest that irbesartan has a lower fetal transfer and less adverse fetal effect compared to olmesartan.
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研究種目 : 基盤研究 (C) (一般)
研究期間 : 2018～2020
課題番号 : 18K06900
研究分野 : 生物薬剤学
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| May 17, 2022 | | インデックス を変更 |
| Nov 14, 2022 | | Creator Name,Creator Kana,Creator Romanization,Creator Affiliation,Creator Affiliation (Translated),Creator Role,Creator Link,Abstract 内容,Note 注記 を変更 |
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