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KAKEN_18K06525seika.pdf
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視床下部室傍核C1q like proteinによるエネルギー代謝調節機序の解明
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シショウカブ シツボウカク C1q like protein ニ ヨル エネルギー タイシャ チョウセツ キジョ ノ カイメイ
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Shishōkabu shitsubōkaku C1q like protein ni yoru enerugī taisha chōsetsu kijo no kaimei
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Regulation of energy metabolism by C1q like protein in hypothalamus
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須山, 成朝
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スヤマ, シゲトモ
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Suyama, Shigetomo
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慶應義塾大学・医学部 (信濃町) ・特任助教
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Research team head
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科研費研究者番号 : 80528414
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柚﨑, 通介
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ユザキ, ミチスケ
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Yuzaki, Michisuke
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Collaborator
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今野, 孝太郎
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コンノ, コウタロウ
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Konno, Koutaro
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2021
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科学研究費補助金研究成果報告書
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2020
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C1qファミリータンパク質はシナプス前部から分泌され、神経伝達物質受容体を集積し、シナプス形成に働く。視床下部の摂食/満腹中枢は末梢のエネルギー代謝情報(ホルモン、栄養素)を受容、統合し、エネルギー代謝恒常性を維持する。 C1qファミリータンパク質の視床下部ニューロンのシナプス伝達を介したエネルギー代謝調節への寄与を検討した。C1ql3は視床下部外側野、弓状核、室傍核及び膵臓ラ氏島に発現し、欠損マウスは、一晩絶食後の有意な過食、顕著な耐糖能を示した。Cbln4は視床下部弓状核の摂食亢進性AgRPニューロンの軸索上に発現し、絶食負荷によりシナプスへ集積し、抑制性シナプスを形成した。
C1q family proteins are secreted from presynaptic terminals, accumulate neurotransmitter receptors, and play a role in synaptogenesis and transmission regulation. The hypothalamic huger / satiety center receives and integrates peripheral energy metabolism information (hormones, nutrients) to maintain energy metabolism homeostasis. Focusing on C1ql3 and Cbln4, which belong to the C1q family, we investigated their contribution to systemic energy metabolism through synaptic transmission of hypothalamic neurons.
C1ql3 is expressed in the lateral hypothalamus, arcuate nucleus, paraventricular nucleus and pancreatic islet, and C1ql3 deficient mice show significant overeating after fasting and marked glucose tolerance. Cbln4 was observed on the axons of AgRP neurons, which are orexigenic neurons in the arcuate nucleus of the hypothalamus, accumulates at synapses by fasting, and regulates inhibitory synaptic transmission.
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研究種目 : 基盤研究 (C) (一般)
研究期間 : 2018～2020
課題番号 : 18K06525
研究分野 : 神経生理学
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