| Item Type |
Article |
| ID |
|
| Preview |
| Image |
|
| Caption |
|
|
| Full text |
KAKEN_16K15471seika.pdf
| Type |
:application/pdf |
Download
|
| Size |
:85.0 KB
|
| Last updated |
:Sep 21, 2017 |
| Downloads |
: 504 |
Total downloads since Sep 21, 2017 : 504
|
|
| Release Date |
|
| Title |
| Title |
質量分析イメージングによる腎代謝小分子の可視化と虚血腎の病態解明
|
| Kana |
シツリョウ ブンセキ イメージング ニ ヨル ジンタイシャ ショウブンシ ノ カシカ ト キョケツジン ノ ビョウタイ カイメイ
|
| Romanization |
Shitsuryo bunseki imejingu ni yoru jintaisha shobunshi no kashika to kyoketsujin no byotai kaimei
|
|
| Other Title |
| Title |
Visualization of small metabolites in the kidney for elucidation of pathophysiology of ischemic nephropathy
|
| Kana |
|
| Romanization |
|
|
| Creator |
| Name |
伊藤, 裕
 |
| Kana |
イトウ, ヒロシ
|
| Romanization |
Ito, Hiroshi
|
| Affiliation |
慶應義塾大学・医学部・教授
|
| Affiliation (Translated) |
|
| Role |
Research team head
|
| Link |
科研費研究者番号 : 40252457
|
| Name |
久保, 亜紀子
|
| Kana |
クボ, アキコ
|
| Romanization |
Kubo, Akiko
|
| Affiliation |
慶應義塾大学・医学部・特任講師
|
| Affiliation (Translated) |
|
| Role |
Research team member
|
| Link |
科研費研究者番号 : 50455573
|
| Name |
宮下, 和季
|
| Kana |
ミヤシタ, カズトシ
|
| Romanization |
Miyashita, Kazutoshi
|
| Affiliation |
慶應義塾大学・医学部・専任講師
|
| Affiliation (Translated) |
|
| Role |
Research team member
|
| Link |
科研費研究者番号 : 50378759
|
|
| Edition |
|
| Place |
|
| Publisher |
|
| Date |
| Issued (from:yyyy) |
2017
|
| Issued (to:yyyy) |
|
| Created (yyyy-mm-dd) |
|
| Updated (yyyy-mm-dd) |
|
| Captured (yyyy-mm-dd) |
|
|
| Physical description |
|
| Source Title |
| Name |
科学研究費補助金研究成果報告書
|
| Name (Translated) |
|
| Volume |
|
| Issue |
|
| Year |
2016
|
| Month |
|
| Start page |
|
| End page |
|
|
| ISSN |
|
| ISBN |
|
| DOI |
|
| URI |
|
| JaLCDOI |
|
| NII Article ID |
|
| Ichushi ID |
|
| Other ID |
|
| Doctoral dissertation |
| Dissertation Number |
|
| Date of granted |
|
| Degree name |
|
| Degree grantor |
|
|
| Abstract |
腎臓は生体の水分・電解質の恒常性維持に重要な役割を果たす。アデノシンは腎機能と腎血流の重要な規定因子として知られているが, アデノシンの腎臓における分布は知られていない。MALDI-IMSは, 臓器内の小分子を可視化する新しい手法である。本研究では, MALDI-IMSを用いて, 腎臓内の代謝小分子の可視化を試みた。腎臓における多くの代謝小分子は, MALDI-IMSにて半定量的に可視化が可能であった。アデノシンは腎皮髄境界の外側線条に特徴的な集積を呈していた。このことから, 血圧変動に応じた髄質血流の調節において, アデノシンが重要な役割を果たす可能性が示唆された。
The kidney plays an essential role in the maintenance of physiological homeostasis of fluid and electrolytes in the body. Adenosine is a well known regulator of renal function and blood flow ; however, the normal distribution of adenosine in the kidney has not been well elucidated. Matrix-assisted laser desorption/ionization (MALDI) - imaging mass spectrometry (IMS) is a novel technology for visualizing the distributions of molecules in situ. Small metabolites in the kidney has not been examined by the method thus far. In the present study, we identified a remarkable accumulation of adenosine in outer stripes of outer medulla (OSOM). The local accumulation of adenosine in OSOM may play a significant role for the physiological functions of adenosine such as the regulation of interstitial blood flow in the kidney.
|
|
| Table of contents |
|
| Keyword |
|
| NDC |
|
| Note |
研究種目 : 挑戦的萌芽研究
研究期間 : 2016～2016
課題番号 : 16K15471
研究分野 : 内分泌学, 代謝学, 腎臓内科学
|
|
| Language |
|
| Type of resource |
|
| Genre |
|
| Text version |
|
| Related DOI |
|
| Access conditions |
|
| Last modified date |
|
| Creation date |
|
| Registerd by |
|
| History |
|
| Index |
|
| Related to |
|
