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KAKEN_16K14567seika.pdf
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| Title |
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神経細胞が細胞死を免れる機構の解明
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| Kana |
シンケイ サイボウ ガ サイボウシ オ マヌガレル キコウ ノ カイメイ
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Shinkei saibo ga saiboshi o manugareru kiko no kaimei
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Mechanisms of neuronal cell death and survival
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仲嶋, 一範
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ナカジマ, カズノリ
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Nakajima, Kazunori
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| Affiliation |
慶應義塾大学・医学部・教授
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Research team head
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科研費研究者番号 : 90280734
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本田, 岳夫
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| Kana |
ホンダ, タカオ
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Honda, Takao
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慶應義塾大学・医学部・講師
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Research team member
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科研費研究者番号 : 30365225
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久保, 健一郎
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| Kana |
クボ, ケンイチロウ
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Kubo, Kenichiro
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慶應義塾大学・医学部・講師
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Research team member
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科研費研究者番号 : 20348791
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2017
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科学研究費補助金研究成果報告書
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2016
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| Abstract |
マウスの全大脳半球培養の際に大量の神経細胞死が生じることを確認し, ある特定の培地成分の有無によって神経細胞死が大きく影響を受けることを発見した。この成分が神経細胞死を誘導する機構を検討し, 分子的機序の一部を明らかにした。さらに, この成分による神経細胞死誘導を阻害できる薬剤を見出した。
また, マウス胎生期に一過的に虚血にして神経細胞死等を誘導した際に発現が変動する分子群を同定し, 変化の大きいシグナル経路を同定した。
We found that massive neuronal cell death occurred during culture of mouse cerebral cortex and that a certain component in the culture medium was important for this cell death induction. We have therefore analyzed the mechanism of this cell death, and have discovered a drug that could prevent the cell death by inhibiting this mechanism.
We have also identified a set of genes whose expression was changed dramatically when mouse embryos had been exposed to transient ischemia.
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研究種目 : 挑戦的萌芽研究
研究期間 : 2016～2016
課題番号 : 16K14567
研究分野 : 発生神経生物学
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