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KAKEN_16K11380seika.pdf
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Download
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:383.4 KB
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:Nov 14, 2022 |
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Total downloads since Nov 14, 2022 : 317
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KIAA1199の皮膚・創傷における機能解析
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| Kana |
KIAA1199 ノ ヒフ・ソウショウ ニ オケル キノウ カイセキ
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KIAA1199 no hifu sōshō ni okeru kinō kaiseki
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Functional analysis of KIAA1199 in skin wound healing
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荒牧, 典子
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アラマキ, ノリコ
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Aramaki, Noriko
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| Affiliation |
慶應義塾大学・医学部 (信濃町) ・講師
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Research team head
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科研費研究者番号 : 80365311
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貴志, 和生
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キシ, カズオ
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Kishi, Kazuo
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慶應義塾大学・医学部 (信濃町) ・教授
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Research team member
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科研費研究者番号 : 40224919
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下田, 将之
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シモダ, マサユキ
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Shimoda, Masayuki
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慶應義塾大学・医学部 (信濃町) ・准教授
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Research team member
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科研費研究者番号 : 70383734
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2020
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科学研究費補助金研究成果報告書
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2019
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今回我々は、新規ヒアルロン酸分解酵素であるKIAA1199のノックアウトマウスを用いた成獣および胎仔創傷治癒過程を検討することで、皮膚・皮膚創傷におけるKIAA1199の機能解析を行うこととした。創傷治癒過程におけるKIAA1199の機能解析を行った報告はこれまでになく、今回の我々の研究結果から、KIAAの欠損が創傷治癒過程、特に瘢痕形成期に影響を与えることが示唆された。今回の研究では、血管新生についての検討がまだなされていないため、今後解析の必要があると考えているが、今後瘢痕抑制などの治療応用への可能性が期待できる。
In this study, we analyze the function of KIAA1199 in skin and cutaneous wounds by investigating the healing process of adult and fetal wounds using knockout mice of the new hyaluronan degrading enzyme KIAA1199. There have been no previous reports of functional analysis of KIAA1199 in the wound healing process, our data suggested that KIAA deficiency affects the wound healing process, especially the stage of scar formation. Since we have not conducted research on angiogenesis in this study, it is thought that future analysis is necessary, but it is expected to be applied to treatments such as scar management in the future.
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研究種目 : 基盤研究 (C) (一般)
研究期間 : 2016～2019
課題番号 : 16K11380
研究分野 : 創傷治癒
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| Mar 5, 2021 | | インデックス を変更 |
| Nov 14, 2022 | | Creator Name,Creator Kana,Creator Romanization,Creator Affiliation,Creator Affiliation (Translated),Creator Role,Creator Link,Abstract 内容,Note 注記 を変更 |
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