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KAKEN_16K10699seika.pdf
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Download
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:Oct 31, 2019 |
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難治組織肺癌である肺多形癌の病態解明・治療開発を目指した分子病理学的研究
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ナンチ ソシキ ハイガン デ アル ハイ タケイガン ノ ビョウタイ カイメイ・チリョウ カイハツ オ メザシタ ブンシ ビョウリガクテキ ケンキュウ
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Nanchi soshiki haigan de aru hai takeigan no byōtai kaimei chiryō kaihatsu o mezashita bunshi byōrigakuteki kenkyū
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Pathological and molecular study of lung pleomorphic carcinomas to clarify the pathogenesis and develop novel treatment strategy
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菱田, 智之
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ヒシダ, トモユキ
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Hishida, Tomoyuki
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慶應義塾大学・医学部 (信濃町)・准教授
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Research team head
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科研費研究者番号 : 40544664
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栗山, 翔司
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クリヤマ, ショウジ
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Kuriyama, Shōji
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Collaborator
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中込, 貴博
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ナカゴミ, タカヒロ
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Nakagomi, Takahiro
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Collaborator
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2019
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科学研究費補助金研究成果報告書
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2018
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肺癌の中でも特に高悪性度である、多形癌を含む「肉腫様成分を含む肺癌」を対象とし、新規治療開発を目指した臨床病理学的解析を行なった。23例の検討では、5年無再発生存割合は56%。再発は8例 (35%) に認めたが、7例は術後1年以内の再発で、再発後生存期間中央値は3ヶ月であった。一方、5年無再発生存を6例 (26%) に認めた。「肉腫様成分」を含む肺癌は、過去の報告同様、早期再発を来たし再発後予後も不良である一方で、長期無再発生存例も存在することが示唆された。対象症例はDNA断片化が著明であったため、対象を近年の症例から再抽出し、遺伝子異常、DNAメチル化異常のprofilingを行っている。
We performed clinicopathological and molecular study to clarify pathogenesis of lung cancer with sarcomatous component (LCSC) including pleomorphic carcinoma, which has high-grade malignancy. We reviewed our medical record and identified 23 patients who underwent resection for LCSC from 1996 to 2011. The 5-year recurrence-free survival was 56%, and 8 (35%) patients developed recurrence. Among them, 7 had recurrence within 1 year after surgery, and median post-recurrence survival was only 3 months. On the other hand, 5-year recurrence-free survivors were found in 6 (26%) patients, which suggested that LCSC might have 2 groups in terms of biological behavior; the poor outcome group as shown in previous studies and the favorable outcome group. Next, we conducted molecular analysis to clarify biological signatures in sarcomatous component, a characteristic component associating with malignant behavior of LCSC, comparing with non-sarcomatous component and non-cancerous area of each case.
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研究種目 : 基盤研究(C)(一般)
研究期間 : 2016～2018
課題番号 : 16K10699
研究分野 : 呼吸器外科学
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