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KAKEN_16K10223seika.pdf
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自覚的認知機能低下患者における臨床的アルツハイマー病発症前診断法に関する検討
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ジカクテキ ニンチ キノウ テイカ カンジャ ニ オケル リンショウテキ アルツハイマービョウ ハッショウゼン シンダンホウ ニ カンスル ケントウ
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Jikakuteki ninchi kinō teika kanja ni okeru rinshōteki arutsuhaimābyō hasshōzen shindanhō ni kansuru kentō
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Clinical evaluation of preclinical Alzheimer's disease in patients with subjective cognitive decline
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田渕, 肇
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タブチ, ハジメ
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Tabuchi, Hajime
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慶應義塾大学・医学部 (信濃町)・講師
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Research team head
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科研費研究者番号 : 10286578
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2019
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科学研究費補助金研究成果報告書
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2018
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本研究では、認知機能が正常な自覚的認知機能低下高齢者において、アミロイドPET 陽性群と陰性群ではおおむね神経心理学的検査上の差はないが、論理性記憶検査の遅延再生課題の結果では陽性群で成績に低下傾向があることがわかった。また、もの忘れの自覚の程度は抑うつ気分・不安や神経心理学的検査の結果とは関係しないが、アミロイド陰性群ではもの忘れの自覚の程度が言語の流暢性の低下や意欲低下と相関することを確認した。さらにアミロイドPETの結果告知は、陽性・陰性と告知された両群で、告知直後・半年 後・1年後においても評価尺度に有意な変化はみられず、不安や抑うつを増悪させないことが示された。
The present study found that Aβ accumulation in cognitively normal research participants with subjective cognitive decline (SCD) might be predicted by the score change from immediate recall to delayed recall of the logical memory, whereas no significant differences were observed between Aβ-positive and negative SCD groups. Also, subjective memory decline correlated with verbal fluency and amotivation in Aβ-negative individuals with SCD. Disclosing amyloid status to SCD did not cause significant long-term psychological risks. However, our findings suggested that those who fill criteria of SCD will include a possible high-risk subgroup for exacerbated distress after learning their negative amyloid PET results. Participants with high levels of anxiety before enrolment were more likely to have test-related distress one year after learning their amyloid negative results.
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研究種目 : 基盤研究(C)(一般)
研究期間 : 2016~2018
課題番号 : 16K10223
研究分野 : 老年精神医学
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