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KAKEN_15K08565seika.pdf
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Title |
Title |
プラセボ効果の個体間変動要因の解析と効果的カウンセリングへの応用
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Kana |
プラセボ コウカ ノ コタイカン ヘンドウ ヨウイン ノ カイセキ ト コウカテキ カウンセリング エノ オウヨウ
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Purasebo kōka no kotaikan hendō yōin no kaiseki to kōkateki kaunseringu eno ōyō
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Factor analysis of individual difference for placebo effect and counseling therapy of medicine
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井澤, 美苗
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Kana |
イサワ, ミナエ
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Romanization |
Isawa, Minae
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慶應義塾大学・薬学部・研究員
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Research team head
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科研費研究者番号 : 10338006
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中島, 恵美
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ナカシマ, エミ
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Nakashima, Emi
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慶應義塾大学・薬学部・教授
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Research team member
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科研費研究者番号 : 90115254
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酒谷, 薫
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サカタニ, カオル
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Sakatani, Kaoru
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日本大学・工学部・教授
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Research team member
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科研費研究者番号 : 90244350
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望月, 眞弓
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モチズキ, マユミ
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Romanization |
Mochizuki, Mayumi
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Affiliation |
慶應義塾大学・薬学部・教授
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Research team member
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科研費研究者番号 : 60292679
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2018
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科学研究費補助金研究成果報告書
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2017
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Abstract |
プラセボ効果は全ての医薬品に存在し, 薬効の大きさを決定づける因子の一つである。プラセボレスポンダーとノンレスポンダーを区別するためにカフェインとプラセボ(乳糖)の比較試験を行った。脳内化学伝達物質・セトロニントランスポーター(5-HT)遺伝子のlong allele home-genotypeを持つ被験者においてプラセボ活性が高いことを見出した。さらにCatechol-O-methyl transferase(COMT)はプラセボ効果との関連性が高いとの報告もあり研究に着手した。
薬剤師の専門分野である服薬説明で薬効が増大するのは, 脳への働きかけであり, その個人差を調べるために臨床試験を行った。
Patients benefit from drug therapy not only through pharmacological mechanisms, but also through non-phar macological action (placebo effect), which may be mediated in part by the prefrontal area of the brain. We consider that the difference between responders and non-responders to placebo might be related to polymorphisms in the serotonin transporter-linked polymorphic region (5-HTTLPR). Nevertheless, it is worth noting that polymorphisms of catechol-O-methyltransferase (COMT) also influence drug effects.
An explanation to patients of the anticipated pharmacological effects of drugs may serve to improve compliance and to enhance treatment benefit via subjective factors. Therefore, counseling may influence the magnitude of the placebo effect. We aimed to examine the effectiveness of counseling (advice to subjects about its expected efficacy) as a means of improving the stress-reducing efficacy of a revitalizingmedicinal product, using both subjective and objective indicators.
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研究種目 : 基盤研究(C)(一般)
研究期間 : 2015~2017
課題番号 : 15K08565
研究分野 : 医療薬学・個別薬物療法
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