| Item Type |
Article |
| ID |
|
| Preview |
| Image |
|
| Caption |
|
|
| Full text |
KAKEN_19K07716seika.pdf
| Type |
:application/pdf |
Download
|
| Size |
:233.6 KB
|
| Last updated |
:Dec 23, 2024 |
| Downloads |
: 62 |
Total downloads since Dec 23, 2024 : 62
|
|
| Release Date |
|
| Title |
| Title |
LncRNAを標的とした新規薬剤抵抗性造血器腫瘍の克服
|
| Kana |
LncRNA オ ヒョウテキ トシタ シンキ ヤクザイ テイコウセイ ゾウケツキ シュヨウ ノ コクフク
|
| Romanization |
LncRNA o hyōteki toshita shinki yakuzai teikōsei zōketsuki shuyō no kokufuku
|
|
| Other Title |
| Title |
Overcoming resistance to new drug in hematological malignancy targeting LncRNA.
|
| Kana |
|
| Romanization |
|
|
| Creator |
| Name |
市川, 大樹
 |
| Kana |
イチカワ, ダイジュ
|
| Romanization |
Ichikawa, Daiju
|
| Affiliation |
慶應義塾大学・薬学部 (芝共立) ・助教
|
| Affiliation (Translated) |
|
| Role |
Research team head
|
| Link |
科研費研究者番号 : 60462793
|
|
| Edition |
|
| Place |
|
| Publisher |
|
| Date |
| Issued (from:yyyy) |
2022
|
| Issued (to:yyyy) |
|
| Created (yyyy-mm-dd) |
|
| Updated (yyyy-mm-dd) |
|
| Captured (yyyy-mm-dd) |
|
|
| Physical description |
|
| Source Title |
| Name |
科学研究費補助金研究成果報告書
|
| Name (Translated) |
|
| Volume |
|
| Issue |
|
| Year |
2021
|
| Month |
|
| Start page |
|
| End page |
|
|
| ISSN |
|
| ISBN |
|
| DOI |
|
| URI |
|
| JaLCDOI |
|
| NII Article ID |
|
| Ichushi ID |
|
| Other ID |
|
| Doctoral dissertation |
| Dissertation Number |
|
| Date of granted |
|
| Degree name |
|
| Degree grantor |
|
|
| Abstract |
本研究では多発性骨髄腫におけるレナリドミド感受性についてDNA microarray・GSEA解析により, レナリドミド感受性細胞株で高発現するlncRNAを3種類(XIST, OVAAL, LINC02397)を同定した. さらにXISTlowOVAALhigh LINC02937low患者において有意に予後不良であり, GSEAの結果より多発性骨髄腫の予後不良に関与する遺伝子群"ZHAN MULTIPLE MYELOMA MS UP"がエンリッチされていた. このエンリッチされた遺伝子群中の1遺伝子がレナリドミド抵抗性に寄与することを過剰発現系などの結果より明らかとした.
In this study, we focused on the mechanism of lncRNA to IMiDs resistance in multiple myeloma (MM). We identified 3 lncRNAs (XIST, OVAAL, LINC02397) that are up-regulated in lenalidomide-sensitive MM cell lines using DNA microarray and GSEA. Moreover, MMRF-CoMMpass study indicated that patients with XISTlowOVAALhigh LINC02937low expressions are a significantly shorter overall survival (OS) in comparison to patients with XISThighOVAALlow LINC02937high expressions. GSEA data also showed that the gene set "ZHAN MULTIPLE MYELOMA MS UP" involved in the poor prognosis of multiple myeloma was enriched. We demonstrate that one gene in the enriched gene set contributed to lenalidomide resistance by the results of in vitro assays.
|
|
| Table of contents |
|
| Keyword |
|
| NDC |
|
| Note |
研究種目 : 基盤研究 (C) (一般)
研究期間 : 2019～2021
課題番号 : 19K07716
研究分野 : 分子生物学に基づくがん免疫学
|
|
| Language |
|
| Type of resource |
|
| Genre |
|
| Text version |
|
| Related DOI |
|
| Access conditions |
|
| Last modified date |
|
| Creation date |
|
| Registerd by |
|
| History |
|
| Index |
|
| Related to |
|
