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KAKEN_17H06270seika.pdf
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:413.4 KB
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:Nov 14, 2022 |
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代謝産物を介した多細胞間ネットワークの統合的解析による臓器機能in toto把握
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タイシャ サンブツ オ カイシタ タサイボウカン ネットワーク ノ トウゴウテキ カイセキ ニ ヨル ゾウキ キノウ in toto ハアク
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Taisha sanbutsu o kaishita tasaibōkan nettowāku no tōgōteki kaiseki ni yoru zōki kinō in toto haaku
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In toto understanding of organ function by integrated analysis of multicellular networks mediated by intercellular delivery of metabolites
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伊藤, 裕
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イトウ, ヒロシ
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Itō, Hiroshi
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慶應義塾大学・医学部 (信濃町) ・教授
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Research team head
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科研費研究者番号 : 40252457
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宮下, 和季
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ミヤシタ, カズトシ
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Miyashita, Kazutoshi
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慶應義塾大学・医学部 (信濃町) ・特任准教授
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Research team member
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科研費研究者番号 : 50378759
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2020
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科学研究費補助金研究成果報告書
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2019
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本研究では個別の臓器, 細胞, 分子にとらわれず、代謝産物の細胞間送達による臓器機能の維持と、その破綻に伴う非感染性疾患の発症・進展について検討した。新しい解析手法である質量分析イメージジング法やメタボロームを駆使して、これまで把握が困難であった低分子代謝産物の、臓器機能制御における意義を明らかにした。非感染性疾患の発症に妊娠時の成育環境や、母体腸内細菌叢由来の代謝産物が影響を与えることを見出した。代謝産物送達の観点から臓器機能とその破綻病態を理解する試みは、細胞内での分子機能解析に基づく既存の分子生物学的アプローチとは異なるものであり、挑戦的研究にふさわしい独創性のある成果をもたらした。
In this study, we aimed to understand the pathophysiology of non-communicable diseases (NCDs) from the alterations in intercellular delivery of metabolites. By utilizing novel technologies such as mass imaging analysis and metabolome, we clarified the significance of low-molecular weight metabolites for organ function. We pointed out the roles for metabolites derived from maternal microbiota in the development of obesity and diabetes of the offspring in mice. The novel understanding of organ function from the perspective of intercellular delivery of metabolites is different from existing approach of the molecular biology which analyzes molecular function in the cell. It has brought novel results with plenty of originality that are suitable for grant-in-aid for exploratory research.
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研究種目 : 挑戦的研究 (開拓)
研究期間 : 2017～2019
課題番号 : 17H06270
研究分野 : 内分泌学、代謝学
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| Mar 5, 2021 | | インデックス を変更 |
| Nov 14, 2022 | | Creator Name,Creator Kana,Creator Romanization,Creator Affiliation,Creator Affiliation (Translated),Creator Role,Creator Link,Abstract 内容,Note 注記 を変更 |
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