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KAKEN_16K09373seika.pdf
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肝線維化を抑制するRestorative Macrophageの誘導機序の解明
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カン センイカ オ ヨクセイスル Restorative Macrophage ノ ユウドウ キジョ ノ カイメイ
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Kan sen'ika o yokuseisuru Restorative Macrophage no yūdō kijo no kaimei
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Mechanisms for the induction of anti-fibrotic restorative macrophage in the liver
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Chu, Po-sung
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チョ, ハクショウ
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慶應義塾大学・医学部 (信濃町) ・助教
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Research team head
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科研費研究者番号 : 80570689
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海老沼, 浩利
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エビヌマ, ヒロトシ
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Ebinuma, Hirotoshi
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国際医療福祉大学・医学部・主任教授
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Research team member
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科研費研究者番号 : 20296560
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瀧本, 洋一
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タキモト, ヨウイチ
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Takimoto, Yōichi
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Collaborator
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2019
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科学研究費補助金研究成果報告書
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2018
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| Abstract |
肝線維化消退マウスモデルを用いて、今まで肝線維化を増悪させるとされる自然免疫応答を担う重要な分子TLR4の全肝臓発現量は肝線維化消退期における発現上昇という現象を発見した。
TLR4-Trem2を介する修復性マクロファージ (Restorative Macrophage) の誘導機序を突き止め、更に腸管除菌モデルにてTLR4リガンドが腸管由来である可能性や、また、同マウスモデルおよびHCV駆除後のヒト検体でTGFβ/Foxp-3+制御性T細胞の上昇を認めることから肝再生・肝内免疫細胞微小環境の回復との関連も示した。TLR4が肝線維化消退に寄与するという未だに報告されていない機序の存在が示唆された。
Liver cirrhosis, the end-stage of any chronic liver disease, is the leading cause of mortality and disability globally. By using murine liver fibrosis resolution models, we demonstrate that TLR4, which generally considered as pro-inflammatory and pro-fibrogenetic, also play a key role in fibrosis resolution, especially is mandatory for restorative macrophage induction through the TLR4-trem2 pathway. Through the gut-liver axis, TLR4 ligands needed for this process are provided. Subsequent liver regeneration are influenced by TGF-β/Foxp3+ Treg induced during fibrosis resolution. Our findings might provide critical insight to restorative macrophage induction as a novel anti-cirrhotic therapy in the future.
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研究種目 : 基盤研究 (C) (一般)
研究期間 : 2016～2018
課題番号 : 16K09373
研究分野 : 肝臓病学、肝線維化、肝不全
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