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KAKEN_16K19954seika.pdf
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| Title |
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IL-8/CXCR2を標的とした食道扁平上皮癌新規治療薬の開発
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| Kana |
IL-8/CXCR2 オ ヒョウテキ ト シタ ショクドウ ヘンペイ ジョウヒガン シンキ チリョウヤク ノ カイハツ
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IL-8/CXCR2 o hyōteki to shita shokudō henpei jōhigan shinki chiryōyaku no kaihatsu
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Development of new therapeutic agents targeting IL-8/CXCR2 network for esophageal squamous cell carcinoma
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井上, 正純
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イノウエ, マサズミ
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Inoue, Masazumi
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慶應義塾大学・医学部(信濃町)・助教
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Research team head
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科研費研究者番号 : 10627136
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竹内, 裕也
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タケウチ, ヒロヤ
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Takeuchi, Hiroya
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Research team member
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松田, 祐子
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マツダ, サチコ
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Matsuda, Sachiko
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Research team member
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2018
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科学研究費補助金研究成果報告書
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2017
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| Abstract |
食道扁平上皮癌切除例における癌組織中のIL-8とCXCR2の発現を検討したところ, IL-8/CXCR2共発現例で有意に術後無再発生存割合及び全生存割合が不良だったことからIL-8/CXCR2シグナルが食道扁平上皮癌細胞動態に関与していることが示唆された。食道扁平上皮癌細胞株を用いた実験ではin vitroにおいてIL-8/CXCR2シグナルを外因的・内因的に刺激すると細胞増殖は亢進し, 外因的・内因的に抑制すると細胞増殖が抑制された。ヌードマウスを用いたin vivo実験でも同様の結果を得たことから, IL-8/CXCR2シグナル伝達が食道扁平上皮癌の細胞増殖に関与していることが示唆された。
In this study, we demonstrated that a positive IL-8 and CXCR2 expression correlates significantly with a lower recurrence-free survival rate and overall survival rate in our esophageal squamous cell carcinoma (ESCC) patient population. These results suggest that IL-8/CXCR2 expression in ESCC has a direct impact on the cellular kinetics of ESCC. In vivo, Both internal and external stimulation or inhibition of the IL-8/CXCR2 network resulted in significant enhancement or suppression of cell proliferation in ESCC cell line. In vivo, stimulation or inhibition of the IL-8/CXCR2 network also resulted in enhancement or suppression of ESCC tumor proliferation. Our results demonstrated that stimulation of the IL-8/CXCR2 network clearly enhanced ESCC cell proliferation, while its inhibition obviously suppressed ESCC cell proliferation in vitro. These results indicate that control of IL-8/CXCR2 network signaling may be a new therapeutic strategy for ESCC.
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研究種目 : 若手研究(B)
研究期間 : 2016～2017
課題番号 : 16K19954
研究分野 : 消化器外科学
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