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KAKEN_15K11267seika.pdf
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Download
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:168.1 KB
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:Nov 12, 2018 |
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フィーダーフリー・ゼノフリー治療用ヒトiPS細胞による下歯槽神経再生への挑戦
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フィーダーフリー・ゼノフリー チリョウヨウ ヒト iPS サイボウ ニ ヨル カシソウ シンケイ サイセイ エノ チョウセン
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Fīdāfurī zenofurī chiryōyō hito iPS saibō ni yoru kashisō shinkei saisei eno chōsen
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Challenge to inferior alveolar nerve regeneration by human iPS cells for feeder-free and xeno-free system
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河奈, 裕正
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カワナ, ヒロマサ
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Kawana, Hiromasa
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慶應義塾大学・医学部(信濃町)・准教授
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Research team head
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科研費研究者番号 : 50224803
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森川, 暁
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モリカワ, サトル
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Morikawa, Satoru
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慶應義塾大学・医学部(信濃町)・専任講師
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Research team member
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科研費研究者番号 : 00424169
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2018
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科学研究費補助金研究成果報告書
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2017
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本研究課題はiPS細胞から神経堤細胞を誘導し, 損傷神経組織の機能回復を目指す戦略を立てた。将来的な細胞治療を念頭に置き, 動物由来の成分を使用しないフィーダーフリー, ゼノフリーでのiPS細胞培養法と, その状態から神経堤細胞への誘導方法を確立した。誘導した神経堤細胞集団が実際に末梢神経損傷を回復させるポテンシャルを有するかどうかを検証するため, 坐骨神経切断モデルの作製とその機能評価に着手した。移植した誘導神経堤細胞は間葉系幹細胞の性質ももっていることがわかっており, 移植実験においても末梢神経マーカーを発現しつつ, 血管内皮細胞も再生神経組織内に誘導できていることを確認できた。
The present study aims to induce neural crest cells from iPS cells and restore function of damaged nerve tissue. We established iPS cell culture method with feeder-free, xeno-free system for inducing neural crest cells. In order to investigate whether the induced neural crest cell population actually has the potential to restore peripheral nerve injury, we started the creation of the sciatic nerve cutting model and its functional evaluation. We found that transplanted induced neural crest cells possess the properties of mesenchymal stem cells and vascular endothelial cells that could also be induced into regenerating nerve tissues. These cells expressed peripheral nerve markers in transplantation tissues.
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研究種目 : 基盤研究(C)(一般)
研究期間 : 2015～2017
課題番号 : 15K11267
研究分野 : 口腔外科学
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