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KAKEN_26463023seika.pdf
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Download
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:281.2 KB
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:Sep 21, 2017 |
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Total downloads since Sep 21, 2017 : 212
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| Title |
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遺伝子改変マウスを用いた天疱瘡自己抗体病原性の評価法開発
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イデンシ カイヘン マウス オ モチイタ テンポウソウ ジコ コウタイ ビョウゲンセイ ノ ヒョウカホウ カイハツ
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Idenshi kaihen mausu o mochiita tenposo jiko kotai byogensei no hyokaho kaihatsu
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Development of pathogenic activity of pemphigus using transgenic mice
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角田, 和之
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ツノダ, カズユキ
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Tsunoda, Kazuyuki
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慶應義塾大学・医学部・専任講師
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Research team head
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科研費研究者番号 : 60265915
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中川, 種昭
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ナカガワ, タネアキ
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Nakagawa, Taneaki
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慶應義塾大学・医学部・教授
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Research team member
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科研費研究者番号 : 00227745
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加藤, 伸
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カトウ, シン
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Kato, Shin
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慶應義塾大学・医学部・助教
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Research team member
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科研費研究者番号 : 80383719
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小高, 利絵
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コダカ, リエ
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Kodaka, Rie
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藤田, 康平
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フジタ, コウヘイ
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Fujita, Kohei
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Research team member
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2017
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科学研究費補助金研究成果報告書
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2016
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| Abstract |
天疱瘡は粘膜と皮膚に生じる自己免疫性の水疱形成疾患である。尋常性天疱瘡患者は全例で口腔粘膜に水疱を形成する。天疱瘡の病態には自己抗体の病原性が大きく関与しており, 自己抗体価と病勢には一定の相関関係が認められることが確認されている。しかし実際の臨床では抗体価と病気の重症度が一致しない症例が数多く存在する。そこで本研究では天疱瘡自己抗体の新たな病原性評価法を開発し臨床応用を目指すことを目的とした。
Pemphigus is an autoimmune blistering disease of skin and oral mucosa. The all of patients with pemphigus vulgaris have a blister in oral mucosa. Many of cases, pathogenic activity of the autoantibody correlate with clinical phenotype of the pemphigus, and it is confirmed their correlation. However, there are many cases that severity of clinical phenotype does not correlate with antibody titers. Therefore, we tried to develop a novel system to measure the pathogenic activity of the pemphigus autoantibody in this study.
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研究種目 : 基盤研究(C)(一般)
研究期間 : 2014～2016
課題番号 : 26463023
研究分野 : 口腔粘膜疾患
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