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KAKEN_24390374seika.pdf
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Download
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:99.2 KB
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| Last updated |
:Apr 11, 2016 |
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Total downloads since Apr 11, 2016 : 850
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| Title |
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腎細胞癌における上皮間葉転換に着目した新規標的分子の探索
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| Kana |
ジンサイボウガン ニ オケル ジョウヒ カンヨウ テンカン ニ チャクモクシタ シンキ ヒョウテキ ブンシ ノ タンサク
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Jinsaibogan ni okeru johi kanyo tenkan ni chakumokushita shinki hyoteki bunshi no tansaku
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Elucidation of molecular targets based on epithelial-mesenchymal transition for the treatment of renal cell carcinoma
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大家, 基嗣
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オオヤ, モトツグ
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Oya, Mototsugu
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慶應義塾大学・医学部・教授
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Research team head
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科研費研究者番号 : 00213885
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三上, 修治
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| Kana |
ミカミ, シュウジ
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Mikami, Shuji
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| Affiliation |
慶應義塾大学・医学部・講師
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Research team member
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科研費研究者番号 : 20338180
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菊地, 栄次
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キクチ, エイジ
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Kikuchi, Eiji
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| Affiliation |
慶應義塾大学・医学部・講師
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Research team member
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科研費研究者番号 : 10286552
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中川, 健
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ナカガワ, ケン
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Nakagawa, Ken
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東京歯科大学・歯学部・教授
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Research team member
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科研費研究者番号 : 50227740
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水野, 隆一
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ミズノ, リュウイチ
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Mizuno, Ryuichi
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| Affiliation |
慶應義塾大学・医学部・講師
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Research team member
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科研費研究者番号 : 60383824
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浅沼, 宏
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アサヌマ, ヒロシ
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Asanuma, Hiroshi
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| Affiliation |
慶應義塾大学・医学部・講師
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Research team member
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科研費研究者番号 : 70245570
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宮嶋, 哲
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ミヤジマ, アキラ
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Miyajima, Akira
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慶應義塾大学・医学部・准教授
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Research team member
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科研費研究者番号 : 90245572
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長田, 浩彦
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ナガタ, ヒロヒコ
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Nagata, Hirohiko
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慶應義塾大学・医学部・研究員
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Research team member
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科研費研究者番号 : 90265900
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2015
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科学研究費補助金研究成果報告書
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2014
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| Abstract |
転移を伴う腎細胞癌に対しては分子標的薬が治療の中心となり, 治療成績は向上した。しかし, 根治が難しいのは薬に効かないがん細胞が残存するからである。我々はこの残存するがん細胞の特徴として, 形態学的には肉腫瘍の変化を伴い, 上皮間葉転換をきたしており, 機序として癌幹細胞のマーカーであるCD44の高発現とTumor Necrosis Factor (TNF)-αによるCD44発現の誘導を発見した。
Molecular targeted agents are widely used and better survival benefits are shown for the treatment of metastatic renal cell carcinoma (RCC). However, there are still hurdles to conquer RCC because survival cancer cells survive. The phenotype survival cancer cells look like sarcoma suggesting epithelial- mesenchymal transition. We found out that CD44 is up-regulated in the cells where Tumor Necrosis Factor (TNF)-α induces the expression.
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研究種目 : 基盤研究(B)
研究期間 : 2012～2014
課題番号 : 24390374
研究分野 : 泌尿器科学, 腫瘍学, 腎臓病学, 透析医学
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