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KAKEN_23592377seika.pdf
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Download
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:178.1 KB
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:Dec 11, 2014 |
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Total downloads since Dec 11, 2014 : 2609
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骨髄由来間葉系幹細胞を用いた閉塞性腎症に対する新規治療方法の確立
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コツズイ ユライ カンヨウケイ カンサイボウ オ モチイタ ヘイソクセイ ジンショウ ニ タイスル シンキ チリョウ ホウホウ ノ カクリツ
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Kotsuzui yurai kanyokei kansaibo o mochiita heisokusei jinsho ni taisuru shinki chiryo hoho no kakuritsu
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New treatment strategy with bone marrow-derived mesenchymal stem cells for obstructive nephropathy
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浅沼, 宏
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アサヌマ, ヒロシ
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Asanuma, Hiroshi
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慶應義塾大学•医学部•講師
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Research team head
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科研費研究者番号 : 70245570
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大家, 基嗣
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オオヤ, モトツグ
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Oya, Mototsugu
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慶應義塾大学•医学部•教授
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Research team member
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科研費研究者番号 : 00213885
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水野, 隆一
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ミズノ, リュウイチ
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Mizuno, Ryuichi
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慶應義塾大学•医学部•講師
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Research team member
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科研費研究者番号 : 60383824
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香野, 日高
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コウノ, ヒダカ
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Kono, Hidaka
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慶應義塾大学•医学部•助教
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Research team member
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科研費研究者番号 : 50338133
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2014
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科学研究費補助金研究成果報告書
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2013
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| Abstract |
閉塞性腎症に対する骨髄由来間葉系幹細胞 (MSC)の注入療法による治療効果をラット片側尿管結紮モデルを用いて検討した。治療後の腎組織を採取して、上皮・間葉系形質転換 (EMT)、腎線維化、それに関与する増殖因子とサイトカインについて評価した。
1) 赤色蛍光標識したヒトおよびラットMSCは、閉塞性腎症モデルの腎間質と尿細管に4週間以上にわたり局在した。2) 閉塞性腎症モデルにおいて、EMTと腎線維化は、MSCの注入により治療後3日～4週間までそれぞれ有意に抑制された。3) MSC注入によるEMTと腎線維化の抑制には、多くの増殖因子やサイトカインのなかでTNF-αの関与が示された。
The effect of mesenchymal stem cells (MSCs) therapy on chronic obstruction-induced renal fibrosis has not previously been evaluated. Rats with left ureteral obstruction underwent injection of fluorescent-labeled human and rat bone marrow-derived MSCs. From 3 days to 4 weeks later, the kidneys were harvested and the renal cortex analyzed for evidence of stem cell infiltration, epithelial-mesenchymal transition (EMT), renal fibrosis, and cytokine and growth factor activity.
MSCs were detected in the interstitium of the kidney more than 4 weeks post-obstruction. MSCs provided protection against obstruction-induced EMT and chronic renal fibrosis. While the mechanism of MSCs-induced renal protection during obstruction remains unclear, exogenous MSCs reduced obstruction-induced TNF-alpha levels, but did not alter TGF-beta1, VEGF, IL-10, FGF, HGF expression.
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研究種目 : 基盤研究(C)
研究期間 : 2011～2013
課題番号 : 23592377
研究分野 : 医歯薬学
科研費の分科・細目 : 外科系臨床医学 泌尿器科学
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