| Item Type |
Article |
| ID |
|
| Preview |
| Image |
|
| Caption |
|
|
| Full text |
KAKEN_26861168seika.pdf
| Type |
:application/pdf |
Download
|
| Size |
:551.7 KB
|
| Last updated |
:Jan 6, 2017 |
| Downloads |
: 455 |
Total downloads since Jan 6, 2017 : 455
|
|
| Release Date |
|
| Title |
| Title |
神経膠芽腫幹細胞の代謝特性の解明
|
| Kana |
シンケイ コウガシュ カンサイボウ ノ タイシャ トクセイ ノ カイメイ
|
| Romanization |
Shinkei kogashu kansaibo no taisha tokusei no kaimei
|
|
| Other Title |
| Title |
Analysis of metabolic characteristics of glioma stem cells
|
| Kana |
|
| Romanization |
|
|
| Creator |
| Name |
Sampetrean, Oltea
 |
| Kana |
サンペトラ, オルテア
|
| Romanization |
|
| Affiliation |
慶應義塾大学・医学部・特任助教
|
| Affiliation (Translated) |
|
| Role |
Research team head
|
| Link |
科研費研究者番号 : 50571113
|
|
| Edition |
|
| Place |
|
| Publisher |
|
| Date |
| Issued (from:yyyy) |
2016
|
| Issued (to:yyyy) |
|
| Created (yyyy-mm-dd) |
|
| Updated (yyyy-mm-dd) |
|
| Captured (yyyy-mm-dd) |
|
|
| Physical description |
|
| Source Title |
| Name |
科学研究費補助金研究成果報告書
|
| Name (Translated) |
|
| Volume |
|
| Issue |
|
| Year |
2015
|
| Month |
|
| Start page |
|
| End page |
|
|
| ISSN |
|
| ISBN |
|
| DOI |
|
| URI |
|
| JaLCDOI |
|
| NII Article ID |
|
| Ichushi ID |
|
| Other ID |
|
| Doctoral dissertation |
| Dissertation Number |
|
| Date of granted |
|
| Degree name |
|
| Degree grantor |
|
|
| Abstract |
神経膠腫幹細胞の代謝特性及び分子背景を解析し, 治療標的となりうる代謝関連因子の同定を目標として研究を行った。具体的には, 悪性神経膠腫のマウスモデルを用いて, 解糖経路を利用する腫瘍幹細胞及びTCA回路を利用する腫瘍幹細胞を樹立し, 代謝特性の解析を行った。その結果, 各々の幹細胞分画について利用する基質及び代謝特性を規定する酵素群を同定した。さらに, TCA回路を利用する神経膠腫幹細胞が低酸素の条件下では柔軟に代謝経路を変えることができ, 代謝可塑性を有することを見出した。
The objective of this study was to analyze the metabolic characteristics of glioma stem cells (GSCs) and identify related targetable factors. With the use of a mouse model of glioblastoma, we established GSCs that rely on glycolysis and GSCs that obtain energy mainly through the tricarboxylic acid cycle and investigated their metabolic characteristics. For each GSC fraction, we identified their preferential substrates and the enzymes supporting their metabolic profile. Furthermore, we showed that GSCs that can use the TCA cycle under normal conditions can flexibly switch to glycolysis in hypoxic conditions and that they display metabolic plasticity.
|
|
| Table of contents |
|
| Keyword |
|
| NDC |
|
| Note |
研究種目 : 若手研究(B)
研究期間 : 2014～2015
課題番号 : 26861168
研究分野 : がん
|
|
| Language |
|
| Type of resource |
|
| Genre |
|
| Text version |
|
| Related DOI |
|
| Access conditions |
|
| Last modified date |
|
| Creation date |
|
| Registerd by |
|
| History |
|
| Index |
|
| Related to |
|
