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KAKEN_26860894seika.pdf
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:276.7 KB
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癌精巣抗原が悪性黒色腫細胞のシグナル伝達と生物活性に及ぼす影響の検討
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ガン セイソウ コウゲン ガ アクセイ コクショクシュ サイボウ ノ シグナル デンタツ ト セイブツ カッセイ ニ オヨボス エイキョウ ノ ケントウ
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Gan seiso kogen ga akusei kokushokushu saibo no shigunaru dentatsu to seibutsu kassei ni oyobosu eikyo no kento
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Effects of cancer-testis antigens on the signaling and biological activity of the malignant melanoma cells
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舩越, 建
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フナコシ, タケル
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Funakoshi, Takeru
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慶應義塾大学・医学部・専任講師
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Research team head
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科研費研究者番号 : 80365353
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種瀬, 啓士
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タネセ, ケイジ
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Tanese, Keiji
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慶應義塾大学・医学部・助教
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Research team member
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科研費研究者番号 : 70464815
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馬場, 裕子
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ババ, ユウコ
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Baba, Yuko
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慶應義塾大学・医学部・助教
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Research team member
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科研費研究者番号 : 10594591
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天谷, 雅行
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アマガイ, マサユキ
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Amagai, Masayuki
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慶應義塾大学・医学部・教授
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Research team member
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科研費研究者番号 : 90212563
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河上, 裕
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カワカミ, ユタカ
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Kawakami, Yutaka
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慶應義塾大学・医学部・教授
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Research team member
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科研費研究者番号 : 50161287
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2016
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科学研究費補助金研究成果報告書
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2015
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| Abstract |
悪性黒色腫において脂質代謝を司る酵素である, Monoacylglycerol lipase(MAGL)が正常メラノサイトに比べて高発現していることを確認した。そこで当院で集積した悪性黒色腫症例を対象として組織におけるMAGLの発現を検討した。MAGLは原発巣よりも転移巣において優位に発現が増強しており, 更に病期の進行とともにMAGLの発現強度が上昇することを確認した。MAGLが発現している症例において血管浸潤像を認める症例が多いことを示した。これらより, MAGLは悪性黒色腫細胞に発現し, 腫瘍の病期進行のバイオマーカー, あるいは原発巣における血管浸潤のバイオマーカーとなり得る可能性が示唆された。
Monoacylglycerol lipase, an enzyme responsible for lipid metabolism in malignant melanoma, was confirmed to be highly expressed in malignant melanoma cells than in normal melanocytes. Then, we examined the expression of MAGL in tissue malignant melanoma cases which were integrated in our hospital as a target. MAGL is predominantly expressed in the metastatic lesions than the primary lesions. And it was confirmed that the expression strength of MAGL rises with the progression of the diseases. Additionally, MAGL showed that there are many cases to admit vascular invasion in cases that have been expressed. From these findings, it is suggested that MAGL has a potential as a biomarker of tumor progression or vascular invasion in the primary lesions.
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研究種目 : 若手研究(B)
研究期間 : 2014～2015
課題番号 : 26860894
研究分野 : 皮膚悪性腫瘍
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