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KAKEN_26560438seika.pdf
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Download
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:160.6 KB
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:Apr 12, 2024 |
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Total downloads since Apr 12, 2024 : 249
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希少糖鎖導入による生体分子・細胞機能改変法の開発
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| Kana |
キショウ トウサ ドウニュウ ニ ヨル セイタイ ブンシ・サイボウ キノウ カイヘンホウ ノ カイハツ
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Kisho tosa donyu ni yoru seitai bunshi saibo kino kaihenho no kaihatsu
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Controlling protein/cell biofunction by chemical introduction of glycans
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小椋, 章弘
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オグラ, アキヒロ
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Ogura, Akihiro
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慶應義塾大学・理工学部・助教
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Research team head
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科研費研究者番号 : 70707843
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2017
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科学研究費補助金研究成果報告書
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2016
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人工糖タンパク質の新しい合成法を開発した。本方法はタンパク質の遺伝子操作を必要とせず, 試薬を加えて温和な条件下反応させるだけで進行し, また従来法よりも遥かに効率的である。合成した人工糖タンパク質をマウスに注射し生体内での挙動を調べた所, 糖鎖の構造によって排出経路や細胞への集積を自在に制御できることがわかった。さらに人工糖タンパク質に金属触媒を結合させておくことで, 生物内の狙った臓器上で有機合成反応を行うことに初めて成功した。
We have developed an efficient strategy for synthesis of artificial glycoprotein. This strategy provides the target molecule just by mixing the reagent under mild conditions and does not need prior genetic modification. The glycoproteins thus synthesized were injected to mice and their in vivo kinetics was analyzed. It was revealed that excretion pathway could be controlled and cell selective accumulation was achieved depending on the glycan structure on the protein. Furthermore, first organ-selective metal-catalyzed organic reaction was realized by attaching metal catalyst onto this artificial glycoprotein.
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研究種目 : 挑戦的萌芽研究
研究期間 : 2014～2016
課題番号 : 26560438
研究分野 : 生物分子化学
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| Apr 12, 2024 | | Creator,Abstract 内容,Note 注記 を変更 |
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