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KAKEN_26461298seika.pdf
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:Sep 21, 2017 |
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Total downloads since Sep 21, 2017 : 843
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自己抗体を介する炎症性筋疾患の臨床像・筋病理の解析と病態機序の解明
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ジコ コウタイ オ カイスル エンショウセイ キンシッカン ノ リンショウゾウ・キン ビョウリ ノ カイセキ ト ビョウタイ キジョ ノ カイメイ
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Jiko kotai o kaisuru enshosei kinshikkan no rinshozo kin byori no kaiseki to byotai kijo no kaimei
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Clinical and histological features of inflammatory myopathies mediated by autoantibodies
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鈴木, 重明
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スズキ, シゲアキ
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Suzuki, Shigeaki
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慶應義塾大学・医学部・講師
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Research team head
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科研費研究者番号 : 50276242
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西野, 一三
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ニシノ, イチゾウ
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Nishino, Ichizo
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大貫, 優子
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オオヌキ, ユウコ
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Onuki, Yuko
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渡邊, 由里香
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ワタナベ, ユリカ
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Watanabe, Yurika
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2017
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科学研究費補助金研究成果報告書
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2016
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免疫介在性壊死性ミオパチー(immune-mediated necrotizing myopathy, IMNM)に関連し抗signal recognition particle(SRP)抗体と抗3-hydroxy-3-methylglutary-coenzyme A reductase(HMGCR) 抗体の意義を明らかにした。IMNM患者において抗SRP抗体が39％, 抗HMGCR抗体が25%で検出され, 抗SRP抗体は抗HMGCR抗体と比べ, 重症例が多かった。HLA-DRB1遺伝子解析からDRB1*08:03と抗SRP抗体, DRB1*11:01と抗HMGCR抗体の関連を証明した。
Immune-mediated necrotizing myopathy (IMNM) is a pathological entity characterized by necrosis in the absence of prominent endomysial lymphocytic infiltration. Autoantibodies against signal recognition particle (SRP) or 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) are associated with IMNM. The frequencies of anti-SRP and anti-HMGCR antibodies in patients with IMNM were 39% and 25%, respectively. Severe limb muscle weakness, neck weakness, dysphagia, respiratory insufficiency, and muscle atrophy were more frequently observed in patients with anti-SRP antibodies than with anti-HMGCR antibodies. HLA-DRB1 genotyping revealed the association of anti-SRP antibodies with DRB1*08:03 and that of anti-HMGCR antibodies with DRB1*11:01.
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研究種目 : 基盤研究(C)(一般)
研究期間 : 2014～2016
課題番号 : 26461298
研究分野 : 神経内科学
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