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KAKEN_26460501seika.pdf
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Title |
胆道領域がんの発がん・増殖・進展にかかわる分子機構の解明と臨床治療への応用
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Kana |
タンドウ リョウイキ ガン ノ ハツガン・ゾウショク・シンテン ニ カカワル ブンシ キコウ ノ カイメイ ト リンショウ チリョウ エノ オウヨウ
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Romanization |
Tando ryoiki gan no hatsugan zoshoku shinten ni kakawaru bunshi kiko no kaimei to rinsho chiryo eno oyo
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Investigation of molecular mechanisms involved in carcinogenesis, proliferation and progression of biliary tract carcinoma and its application to clinical treatment
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尾島, 英知
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オジマ, ヒデノリ
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Ojima, Hidenori
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慶應義塾大学・医学部・准教授
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Research team head
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科研費研究者番号 : 80342905
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2017
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科学研究費補助金研究成果報告書
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2016
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多数の胆道領域がんバイオリソースを用いて, 発がん・増殖・進展に関わる分子機構の解明を行った。その結果, 腫瘍発生部位に関連する4候補遺伝子が見いだされ, 免疫組織学的検討で腫瘍存在部位に一致した発現傾向を得た。腫瘍進展因子IDCC(Intraductal carcinoma component ;上皮内がん成分)に関連する50候補遺伝子の解析では, IDCC陰性群(高悪性度群)に高く発現している遺伝子の多くは転移・浸潤に関連した遺伝子であることが判明し, 臨床病理組的解析結果の裏付けとなった。さらに, これら遺伝子を標的にした新規抗がん剤の前臨床試験も可能なin vitro assay系も確立された。
We have elucidated the molecular mechanisms of carcinogenesis, proliferation and progression of biliary tract carcinoma (BTC) using numerous BTC-related bio-resources. As a result, four candidate genes associated with different sites of tumor locations were found and immunohistochemical study using surgical specimens confirmed the consistency of their expression with the tumor existing sites. Analysis of 50 candidate genes associated with IDCC (Intraductal Carcinoma Component) as one of the histopathological BTC spreading and malignancy factors revealed that many highly expressed genes in the tumor group without IDCC (high-grade group) were involved in tumor malignancy related with metastasis or invasion. This data supported the clinicopathological features of IDCC. Furthermore, we have established in vitro assay system of BTC that enables preclinical study and appropriates parameters for novel anticancer drugs which targeting the above genes.
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研究種目 : 基盤研究(C)(一般)
研究期間 : 2014~2016
課題番号 : 26460501
研究分野 : 医歯薬学
PDFファイルは改訂版に差し替え (2022.3.15)
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Jul 26, 2019 | | 著者,抄録 内容,アクセス条件 を変更 |
Mar 15, 2022 | | Preview,Full text を変更 |
Mar 18, 2022 | | Note 注記 を変更 |
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