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KAKEN_26282212seika.pdf
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:854.7 KB
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:Sep 21, 2017 |
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Total downloads since Sep 21, 2017 : 399
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生体機能光制御分子の創製と細胞機能精密制御への応用
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| Kana |
セイタイ キノウ ヒカリ セイギョ ブンシ ノ ソウセイ ト サイボウ キノウ セイミツ セイギョ エノ オウヨウ
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Seitai kino hikari seigyo bunshi no sosei to saibo kino seimitsu seigyo eno oyo
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Creation of agents that selectively photo-degrade certain proteins and oligosaccharides and its application to control of cell functions
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戸嶋, 一敦
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トシマ, カズノブ
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Toshima, Kazunobu
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慶應義塾大学・理工学部・教授
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Research team head
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科研費研究者番号 : 60217502
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2017
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科学研究費補助金研究成果報告書
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2016
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本研究課題においては, 種々の疾病に関連するさまざまなタンパク及び糖鎖を, 特定波長の光照射によって, 標的選択的に分解する新しい生体機能分子を創製した。さらに, これら生体機能分子が, 疾病に関連する細胞内で機能し, これら細胞の機能を制御可能なことを見出した。これらのことにより, 光照射によって生理活性の発現が制御可能な, これまでに類例のない生体機能光制御分子の開発に向けた新たな指針を確立した。
Several agents, that target-selectively photo-degrade certain disease-related proteins and oligosaccharides, were designed and synthesized. Furthermore, it was found the agents thus developed work not only in test tube but also in disease-related cells. From these studies, a new approach for the design of light-activated and molecular-targeted medicines has been established.
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研究種目 : 基盤研究(B)(一般)
研究期間 : 2014～2016
課題番号 : 26282212
研究分野 : 分子生命化学
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