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KAKEN_25861124seika.pdf
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Download
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:84.7 KB
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:Jan 6, 2017 |
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Total downloads since Jan 6, 2017 : 1015
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小線源治療併用外部放射線治療の線量分布を生物学的に最適化する手法の開発
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ショウセンゲン チリョウ ヘイヨウ ガイブ ホウシャセン チリョウ ノ センリョウ ブンプ オ セイブツガクテキ ニ サイテキカスル シュホウ ノ カイハツ
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Shosengen chiryo heiyo gaibu hoshasen chiryo no senryo bunpu o seibutsugakuteki ni saitekikasuru shuho no kaihatsu
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Biological optimization for brachytherapy combined with external beam radiation therapy
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白石, 悠
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シライシ, ユタカ
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Shiraishi, Yutaka
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慶應義塾大学・医学部放射線治療科・講師
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Research team head
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科研費研究者番号 : 00445339
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萬, 篤憲
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ヨロズ, アツノリ
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Yorozu, Atsunori
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大橋, 俊夫
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オオハシ, トシオ
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Ohashi, Toshio
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花田, 剛士
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ハナダ, タカシ
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Hanada, Takashi
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2016
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科学研究費補助金研究成果報告書
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2015
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| Abstract |
小線源治療の物理線量を生物学的等価線量に変換し直腸のgEUD(generalized Equivalent Uniform Doses)を計算した。その結果, gEUDが増加するほどGrade2直腸出血の頻度が高くなることがわかった。また多変量解析において, gEUDがGrade2直腸出血の有意なリスク因子であることが示された。生物学的等価線量(gEUD)と直腸出血の有無の関係から, 小線源治療と外照射を合算したNTCP(Normal Tissue Complication Probability)の計算方法とNTCP算出に必要なパラメータの値を提案した。
We demonstrated generalized equivalent uniform doses (gEUD) to be a potential predictive factor for grade 2+ late rectal bleeding after I-125 prostate brachytherapy combined with external beam radiation therapy. We tested the NTCP model suggested by the QUANTEC review (quantitative analysis of normal tissue effects in the clinic) of late rectal bleeding dose-volume factors: the Lyman-Kutcher-Burman (LKB) model, using gEUD. This study calculated NTCP parameter values for late rectal bleeding observed in combined therapy.
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研究種目 : 若手研究(B)
研究期間 : 2013～2015
課題番号 : 25861124
研究分野 : 放射線治療
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