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KAKEN_25462800seika.pdf
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| Title |
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自己細胞由来血小板成長因子によるパーソナル治療剤の開発
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ジコ サイボウ ユライ ケッショウバン セイチョウ インシ ニ ヨル パーソナル チリョウザイ ノ カイハツ
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Jiko saibo yurai kesshoban seicho inshi ni yoru pasonaru chiryozai no kaihatsu
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Basic studies on the autologous cure by manufacturing platelets
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矢澤, 真樹
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ヤザワ, マサキ
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Yazawa, Masaki
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慶應義塾大学・医学部・専任講師
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Research team head
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科研費研究者番号 : 60327567
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森, 泰昌
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モリ, タイスケ
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Mori, Taisuke
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国立研究開発法人国立がん研究センター・中央病院・医員
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Research team member
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科研費研究者番号 : 00296708
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松原, 由美子
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マツバラ, ユミコ
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Matsubara, Yumiko
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慶應義塾大学・医学部・特任准教授
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Research team member
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科研費研究者番号 : 70365427
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2017
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科学研究費補助金研究成果報告書
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2016
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| Abstract |
血小板には各種成長因子が多く含まれており, 止血・凝固作用後の傷において, これらの成長因子が複合的に働き, 創部の創傷治癒過程で大きな寄与をしていることが分かってきた。そこで自己細胞由来誘導性血小板を作製してパーソナル治療剤の開発に繋げる本研究を行った。in vitro血小板分化に用いるヒト細胞ソースの検討をはじめに行った。脂肪前駆細胞から作製した血小板は, 創傷治癒に有効性を示すサイトカインを含有し, 刺激による活性化能を有していた。免疫不全創傷治癒モデルマウスを用いた検討を行った。本研究の成果は, 自己細胞由来誘導性血小板を用い, 血小板に含まれる成長因子による, パーソナル治療剤の開発に繋がった。
Platelets are released from mature megakaryocytes and have an essential role in hemostatic plug formation. Recently, a line of evidence supports the clinical application of platelets to accelerate wound healing. However, it is difficult to use peripheral platelets for wide-range wound. Thus, new strategies for manufacturing megakaryocytes and subsequently platelets are urgently needed. Thus, the use of pre-adipocytes from adipose tissues would be advantageous for establishing a culture system to produce platelets for clinical application. Pre-adipocyte-derived platelets have the ability of activation and contain cytokines in relation to wound healing. We also examined the effect of pre-adipocyte-derived platelets on wound healing of immunodeficient NOG mouse with full-thickness excisional wound. Taken together, manufacturing platelets from pre-adipocytes would be advantageous for wound healing.
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研究種目 : 基盤研究(C)(一般)
研究期間 : 2013～2016
課題番号 : 25462800
研究分野 : 医歯薬学
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