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KAKEN_25462278seika.pdf
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Title |
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神経膠腫における個別化治療の確立(特に術前化学療法の適応確立)
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シンケイ コウシュ ニ オケル コベツカ チリョウ ノ カクリツ (トクニ ジュツゼン カガク リョウホウ ノ テキオウ カクリツ)
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Shinkei koshu ni okeru kobetsuka chiryo no kakuritsu (tokuni jutsuzen kagaku ryoho no tekio kakuritsu)
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Towards personalized treatment of gliomas : specifically to explore the indication of neoadjuvant chemotherapy for gliomas
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吉田, 一成
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ヨシダ, カズナリ
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Yoshida, Kazunari
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慶應義塾大学・医学部・教授
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Research team head
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科研費研究者番号 : 70166940
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佐々木, 光
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ササキ, ヒカル
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Sasaki, Hikaru
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慶應義塾大学・医学部・講師
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Research team member
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科研費研究者番号 : 70245512
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2016
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科学研究費補助金研究成果報告書
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2015
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Abstract |
組織学的に星細胞腫系特徴を示す神経膠腫においても, 1p19q共欠失があれば, 共欠失をもつ乏突起膠細胞系腫瘍と同等に良好な予後が期待できることを報告した(Oncotarget)。神経膠腫において, 分子診断に基づいた, 化学療法先行, 残存腫瘍がある場合には化学療法による腫瘍縮小後に摘出, という治療方法が, 単なる化学療法単独よりも有望である可能性を報告した(J Neurooncol)(神経膠腫に対する術前化学療法の前向き研究として世界初)。また, 皮質局在と石灰化があれば, 高い確率で1p19q共欠失が予測されことを報告し, 画像による術前化学療法の適応判断の可能性を示した(Neurosurg Rev)。
Codeletion of chromosomes 1p and 19q is predictive for favorable prognosis in the patients with oligodendroglial tumors. We suggested that gliomas with 1p19q codeletion with some or more "astrocytic" features also had comparable biological and prognostic characteristics to those with oligodendroglial features (Oncotarget). We showed that upfront chemotherapy for molecularly defined chemosensitive gliomas with the intension of second-look resection for initial incomplete resections might compare favorably with chemotherapy only, and suggested the usefulness of neoadjuvant strategy for the first time (J Neurooncol). We found that combination of surface localization and calcification strongly predicted 1p19q codeletion, and these radiological evaluation would help to segregate the candidates to be treated with neoadjuvant strategy (Neurosurg Rev).
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研究種目 : 基盤研究(C)(一般)
研究期間 : 2013~2015
課題番号 : 25462278
研究分野 : 脳神経外科学
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