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KAKEN_25462167seika.pdf
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Download
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:96.7 KB
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:Jan 6, 2017 |
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Total downloads since Jan 6, 2017 : 997
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持続的脊髄冷却法による脊髄冷却効果の実験的検討 : 冷却効率の向上へむけて
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ジゾクテキ セキズイ レイキャクホウ ニ ヨル セキズイ レイキャク コウカ ノ ジッケンテキ ケントウ : レイキャク コウリツ ノ コウジョウ エ ムケテ
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Jizokuteki sekizui reikyakuho ni yoru sekizui reikyaku koka no jikkenteki kento : reikyaku koritsu no kojo e mukete
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Experimental analysis of continuous epidural cooling against spinal cord injury
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吉武, 明弘
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ヨシタケ, アキヒロ
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Yoshitake, Akihiro
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慶應義塾大学・医学部・講師
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Research team head
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科研費研究者番号 : 70327550
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志水, 秀行
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シミズ, ヒデユキ
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Shimizu, Hideyuki
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慶應義塾大学・医学部・教授
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Research team member
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科研費研究者番号 : 50226247
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高木, 秀暢
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タカキ, ヒデノブ
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Takaki, Hidenobu
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東京歯科大学・歯学部・助教
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Research team member
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科研費研究者番号 : 20594683
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2016
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科学研究費補助金研究成果報告書
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2015
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| Abstract |
swine(35～40kg)を用い, A群(低温epidural cooling; 4℃)群, B群(高温epidural cooling; 20℃)群, C群はcontrol群とした。術後12時間後のTarlov scoreはA群B群で, control群に比較して冷却効果を得た。術中MEP消失までの時間はAB群間で有意差はなく, C群と比較すると有意に長かった。手術後, HE染色ではC群でneuronの壊死を著明に認め, 低温冷却群や高温冷却群では脊髄の壊死はほとんど認められず20℃の冷却であっても脊髄保護効果が十分であると思われた。
Eighteen pigs underwent thoracic aortic double clamping for 35 minutes. These are divided into three groups, Gourp A (cooling temperature; 4℃), Group B (20℃), and Goup C (control). Mean time from aortic crossclamping to onset of MEP loss was significantly longer in group A and B than group C. Group A and group Bshowed significantly better neurologic function than that of group C. In group A and group B, motor neurons had a nearly normal appearance, with minimal eosinophilic change in the cytoplasm. Group C motor neurons showed acute necrotic changes. Degenerating neurons were swollen or shrunken.
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研究種目 : 基盤研究(C)(一般)
研究期間 : 2013～2015
課題番号 : 25462167
研究分野 : 心臓血管外科
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