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KAKEN_25461710seika.pdf
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天疱瘡における自己反応性B細胞の活性化機構の解析
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テンポウソウ ニ オケル ジコ ハンノウセイ Bサイボウ ノ カッセイカ キコウ ノ カイセキ
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Tenposo ni okeru jiko hannosei Bsaibo no kasseika kiko no kaiseki
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Analysis of the activation mechanism of autoreactive B cells in pemphigus
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山上, 淳
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ヤマガミ, ジュン
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Yamagami, Jun
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慶應義塾大学・医学部・専任講師
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Research team head
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科研費研究者番号 : 80327618
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高橋, 勇人
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タカハシ, ハヤト
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Takahashi, Hayato
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慶應義塾大学・医学部・専任講師
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Research team member
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科研費研究者番号 : 40398615
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天谷, 雅行
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アマガイ, マサユキ
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Amagai, Masayuki
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慶應義塾大学・医学部・教授
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Research team member
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科研費研究者番号 : 90212563
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2016
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科学研究費補助金研究成果報告書
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2015
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天疱瘡は, 表皮角化細胞同士の接着分子であるデスモグレイン(Dsg)に対する自己抗体により生じる。本研究では, 天疱瘡患者の末梢血中から, 自己抗体産生に関わるB細胞の活性化および分化において重要な役割を果たす濾胞ヘルパーT細胞(Tfh)の検出を試みた。未治療の天疱瘡患者11例の末梢血単核球からCD3およびCD4陽性の細胞集団を展開して, CXCR5およびICOSを高発現している細胞をTfh様細胞として観察した。天疱瘡患者の末梢血単核球では, Tfh様細胞は健常人に比べて有意に高かった。また病勢が制御された後は, 末梢血中のTfh様細胞の割合が有意に減少していた。
Pemphigus is an autoimmune disease caused by IgG autoantibodies against desmogleins (Dsgs). The mechanism of production of anti-Dsg autoantibodies in pemphigus has not been elucidated. In this study, we aimed to establish follicular helper CD4 T cells (Tfhs) that are considered as specialized providers of B cell help in the peripheral blood in pemphigus, We detected Tfh-like cells with high expression levels of CXCR5, PD-1 and ICOS (CD278) on the cell surface in the population of double positive for CD3 and CD4 using peripheral blood monocytes (PBMCs) from 11 patients with pemphigus. The percentage of peripheral Tfh-like cells in CD4+ PBMCs in pemphigus patients without treatment were significantly higher than those in PBMCs from healthy controls. After treatment, the ratio of Tfh-like cells decreased by more than 50% in 10 out of 11 cases with pemphigus, suggesting that the numbers of Tfh-like cells may reflect the disease activities.
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研究種目 : 基盤研究(C)(一般)
研究期間 : 2013～2015
課題番号 : 25461710
研究分野 : 皮膚科
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