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KAKEN_25461520seika.pdf
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宿主と微生物のmiRNAを介したクロストークの解析
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シュクシュ ト ビセイブツ ノ miRNA オ カイシタ クロストーク ノ カイセキ
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Shukushu to biseibutsu no miRNA o kaishita kurosutoku no kaiseki
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An analysis of miRNA related host-microbial crosstalk
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長谷川, 直樹
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ハセガワ, ナオキ
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Hasegawa, Naoki
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慶應義塾大学・医学部・教授
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Research team head
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科研費研究者番号 : 20198724
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星野, 仁彦
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ホシノ, ヨシヒコ
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Hoshino, Yoshihiko
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国立感染症研究所・ハンセン病研究センター感染制御部・室長
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Research team member
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科研費研究者番号 : 20569694
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西村, 知泰
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ニシムラ, トモヤス
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Nishimura, Tomoyasu
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慶應義塾大学・保健管理センター(日吉)・講師
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Research team member
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科研費研究者番号 : 90348649
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2016
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科学研究費補助金研究成果報告書
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2015
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慢性難治性呼吸器感染症である肺Mycobacterium avium complex(MAC)症の疾患活動性の指標となるバイオマーカーの発見, 病態解明および新規治療標的の発見を目的として, 我々は, 肺MAC症に関連するmicro RNA(miRNA)を探索した。
肺MAC症患者と健常者の血清中miRNAプロファイルを比較することで, 肺MAC症に関連するmiRNAとしてhsa-miR-346を発見した。今後, hsa-miR-346と肺MAC症の疾患活動性との関連を更に明確にし, 病態解明そして新しい治療への応用を目指していく。
To figure out the pathophysiology and find biomarkers reflecting disease activity and new therapeutic targets for Mycobacterium avium complex (MAC) pulmonary disease, which is an intractable chronic respiratory infection, we searched micro RNAs (miRNAs) associated with MAC pulmonary disease.
By comparing the profile of serum miRNAs of the patients with that of healthy controls, we determined hsa-miR-346 as a miRNA associated with MAC pulmonary disease. We will evaluate whether this miRNA is a biomarker reflecting disease activity and perform further studies to figure out the pathophysiology of MAC pulmonary disease associated with hsa-miR-346 for novel treatment.
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研究種目 : 基盤研究(C)(一般)
研究期間 : 2013～2015
課題番号 : 25461520
研究分野 : 感染症内科
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