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KAKEN_25460116seika.pdf
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Title |
Title |
和漢薬と西洋薬との併用における適正使用に向けた臨床薬理学的研究
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Kana |
ワカンヤク ト セイヨウヤク トノ ヘイヨウ ニ オケル テキセイ シヨウ ニ ムケタ リンショウ ヤクリガクテキ ケンキュウ
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Romanization |
Wakanyaku to seiyoyaku tono heiyo ni okeru tekisei shiyo ni muketa rinsho yakurigakuteki kenkyu
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Clinical pharmacological study for proper use in combination with Japanese traditional medicine and western medicine
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中村, 智徳
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Kana |
ナカムラ, トモノリ
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Romanization |
Nakamura, Tomonori
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慶應義塾大学・薬学部・教授
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Research team head
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科研費研究者番号 : 30251151
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坡下, 真大
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Kana |
ハシタ, タダヒロ
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Romanization |
Hashita, Tadahiro
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Affiliation |
名古屋市立大学・大学院薬学研究科・講師
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Research team member
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科研費研究者番号 : 20613384
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佐藤, 浩子
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Kana |
サトウ, ヒロコ
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Romanization |
Sato, Hiroko
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Affiliation |
群馬大学・大学院医学系研究科・講師
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Affiliation (Translated) |
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Research team member
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科研費研究者番号 : 50396652
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山本, 康次郎
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Kana |
ヤマモト, コウジロウ
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Romanization |
Yamamoto, Kojiro
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Affiliation |
群馬大学・大学院医学系研究科・教授
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Research team member
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科研費研究者番号 : 70174787
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青森, 達
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Kana |
アオモリ, トオル
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Romanization |
Aomori, Toru
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Affiliation |
慶應義塾大学・薬学部・講師
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Affiliation (Translated) |
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Role |
Research team member
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科研費研究者番号 : 40620802
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鈴木, 小夜
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Kana |
スズキ, サヨ
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Romanization |
Suzuki, Sayo
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Affiliation |
慶應義塾大学・薬学部・講師
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Affiliation (Translated) |
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Research team member
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科研費研究者番号 : 90424134
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地引, 綾
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Kana |
ジビキ, アヤ
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Romanization |
Jibiki, Aya
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Affiliation |
慶應義塾大学・薬学部・助教
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Research team member
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科研費研究者番号 : 00746224
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小林, 典子
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Kana |
コバヤシ, ノリコ
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Romanization |
Kobayashi, Noriko
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Affiliation |
慶應義塾大学・薬学部・助教
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Research team member
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科研費研究者番号 : 90245449
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手塚, 淑人
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Kana |
テズカ, ヨシト
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Romanization |
Tezuka, Yoshito
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Affiliation |
慶應義塾大学・薬学部・助教
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Affiliation (Translated) |
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Research team member
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科研費研究者番号 : 00433649
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Issued (from:yyyy) |
2017
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科学研究費補助金研究成果報告書
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2016
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Abstract |
和漢薬と西洋医薬品との併用の有効性・安全性の評価法確立と, 西洋医薬品の副作用回避のための和漢薬併用を検証する目的で, 群馬大学病院和漢診療科との共同研究を開始し, 胃がんや大腸がんの術後において, モサプリドクエン酸塩に大建中湯を併用することで, 消化管運動促進, 制吐作用等を期待できることが分かった。
慶應義塾大学医学部漢方医学センターとの共同研究では, 甘草やグリチルリチン製剤服用患者での偽アルドステロン症発症は, D-Bil高値やAlb低値の患者で頻度が高く, D-Bil高値の方が精度が高かった。
国立がん研究センター東病院薬剤部との共同研究で, 抗がん薬による吃逆を柿蔕湯が抑制する可能性が示唆された。
In collaboration with Department of General Medicine at Gunma University Hospital for the purpose of establishing the evaluation method of efficacy and safety of combination use of Japanese traditional medicines and Western medicines, and verifying combination case of Japanese medicine for avoiding side effects of Western medicines. Then, it was found that after the operation of gastric or colorectal cancer, it was possible to promote gastrointestinal motility, antiemetic effect and etc by using Daikenchuto with mosapride citrate.
In collaboration with the Center for Kampo Medicine, Keio University School of Medicine, the onset of pseudoaldosteronism in licorice and glycyrrhizin preparations is more frequent in patients with high direct-bilirubin (D-Bil) and low albumin values, and the accuracy was higher in high D-Bil values.
In collaboration with the National Cancer Center Hospital East, it was suggested that Shiteito suppressed the anticancer drug-induced serious hiccups.
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研究種目 : 基盤研究(C)(一般)
研究期間 : 2013~2016
課題番号 : 25460116
研究分野 : 臨床薬理学
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