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KAKEN_25430139seika.pdf
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Title |
Title |
遺伝子発現エントロピー解析による腫瘍不均一性の検証
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イデンシ ハツゲン エントロピー カイセキ ニ ヨル シュヨウ フキンイツセイ ノ ケンショウ
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Idenshi hatsugen entoropi kaiseki ni yoru shuyo fukinitsusei no kensho
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Investigation of tumor heterogeneity based on analyses of transcriptomic entropy
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涌井, 昌俊
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ワクイ, マサトシ
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Wakui, Masatoshi
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慶應義塾大学・医学部・講師
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Research team head
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科研費研究者番号 : 90240465
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2016
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科学研究費補助金研究成果報告書
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2015
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シャノンのエントロピーや相互情報量に代表される情報理論を応用して, 個々の生物学的経路ごとのトランスクリプトームに反映される腫瘍不均一性を定量することに成功した。事実, 複数のヒトがん細胞株の間や異なる酸素環境条件の培養の間で, 腫瘍不均一性に富む代謝経路および乏しい代謝経路が検出された。これらの結果は代謝生物学的見地からの腫瘍不均一性への洞察を与え, 診断・治療への応用の可能性を示唆する。
We successfully applied information theory represented by Shannon's entropy and mutual information to quantification of the tumor heterogeneity reflected in the transcriptome in each of biological pathways. In fact, metabolic pathways exhibiting high or low heterogeneity were detected among a number of human cancer cell lines as well as between different oxygen environments of cell culture. These results provide insights into tumor heterogeneity from the perspective of metabolic biology, suggesting the potential of diagnostic and therapeutic application.
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研究種目 : 基盤研究(C)(一般)
研究期間 : 2013~2015
課題番号 : 25430139
研究分野 : 腫瘍学
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