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KAKEN_24790720seika.pdf
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| Title |
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C型肝炎ウイルス特異的CD8T細胞機能不全の網羅的解析
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Cガタ カンエン ウイルス トクイテキ CD8 Tサイボウ キノウ フゼン ノ モウラテキ カイセキ
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Cgata kanen uirusu tokuiteki CD8 Tsaibo kino fuzen no morateki kaiseki
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Comprehensive analysis of dysfunctional HCV specific CD8 T cell during persistent HCV infection
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石橋, 由佳
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イシバシ, ユカ
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Ishibashi, Yuka
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慶應義塾大学・医学部・助教
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Research team head
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科研費研究者番号 : 60528305
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中本, 伸宏
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ナカモト, ノブヒロ
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Nakamoto, Nobuhiro
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慶應義塾大学・医学部(信濃町)・専任講師
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Research team member
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科研費研究者番号 : 40383749
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2016
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科学研究費補助金研究成果報告書
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2015
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C型慢性肝炎患者のHCV特異的CD8 T細胞は, 同一患者のEBVやinfluenza virus特異的CD8 T細胞と比較してPD-1, CTLA-4, LAG-3などの抑制性補助刺激分子の発現が高く一部の細胞は複数の抑制性補助刺激分子の共発現を認めた。特にHCVウイルス量が多いほど, 複数の抑制性補助刺激分子の発現を認めた。興味深いことにPD-1陽性CD8 T細胞は陰性分画と比較して有意にTNFの産生が低くIL10産生が高い傾向にあり, 上記の結果からHCV持続感染により一部のHCV特異的CD8 T細胞は抑制性補助刺激分子の発現を介して免疫寛容に陥っている可能性が示唆された。
Peripheral HCV specific CD8 T cells in patients with chronic HCV infections showed higher expressions of suppressive co-stimulation molecules such as PD-1, CTLA4, and LAG-3 compared with EBV or influenza specific CD8 T cells from the same individuals. HCV specific CD8 T cells in patients with higher viral load tended to express multiple suppressive co-stimulation molecules. Of interest, PD-1 positive HCV specific CD8 T cells produced higher TNFα and lower IL-10 compared with PD-1 negative subsets. There results suggest that HCV specific CD 8 T cells fall to be dysfunctional via the expression of multiple suppressive co-stimulation molecules during persistent HCV infection. Further study is needed to clarify the mechanism behind the immune tolerance in the liver and to overcome the HCV infection in humans.
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研究種目 : 若手研究(B)
研究期間 : 2012～2015
課題番号 : 24790720
研究分野 : 肝臓免疫
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