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KAKEN_24659375seika.pdf
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Download
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:177.3 KB
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| Last updated |
:Dec 11, 2014 |
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Total downloads since Dec 11, 2014 : 726
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| Title |
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腸炎惹起性記憶T細胞reprogramming細胞療法への挑戦
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チョウエン ジャッキセイ キオク T サイボウ reprogramming サイボウ リョウホウ エノ チョウセン
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Choen jakkisei kioku T saibo reprogramming saibo ryoho eno chosen
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Challenge to the cell therapy by reprogramming colitogenic memory T cells
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金井, 隆典
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カナイ, タカノリ
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Kanai, Takanori
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慶應義塾大学・医学部・教授
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Research team head
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科研費研究者番号 : 40245478
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三上, 洋平
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ミカミ, ヨウヘイ
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Mikami, Yohei
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慶應義塾大学・医学部・助教
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Research team member
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科研費研究者番号 : 80528662
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2014
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科学研究費補助金研究成果報告書
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2013
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炎症性腸疾患(IBD)が再燃するのは、腸炎惹起性メモリー細胞が残存していることが原因であることを報告してきた。本研究は、このメモリー細胞を制御することで、再燃を抑制する治療法の開発につなげることを目的とした。本研究の結果は以下の通りである。1. Th17はLympoid tissue inducer-like cellによって誘導された。2. Classical Th1は、alternative Th1の存在下で腸炎惹起性を獲得した。3. 整腸剤であるClostridium butyricumが、抑制性マクロファージを誘導した。IBDの慢性化には、様々な細胞集団が関与していた。
We reported that the persistence of colitogenic memory cells are responsible for recurrence of inflammatory bowel disease (IBD). This study aimed to investigate the regulation of the colitigenic memory cells, leading to the development of new therapy for suppression of IBD recurrence. The results of the study is as below: 1. Th17 cells were induced under the influence of Lymphoid tissue inducer-like cell, 2. Classical Th1 cells obtained colitogenesity in the presence of alternative Th1 cells, 3. Clostridium butyricum, which is used as probiotics, induced anti-inflammatory macrophages. These results suggest the involvement of various cell types in the development of chronic inflammation of IBD.
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研究種目 : 挑戦的萌芽研究
研究期間 : 2012～2013
課題番号 : 24659375
研究分野 : 医歯薬学
科研費の分科・細目 : 内科系臨床医学・消化器内科学
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