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KAKEN_24592965seika.pdf
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歯周組織幹細胞からみた慢性歯周炎組織破壊と組織リモデリング機序の解明
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シシュウ ソシキ カンサイボウ カラ ミタ マンセイ シシュウエン ソシキ ハカイ ト ソシキ リモデリング キジョ ノ カイメイ
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Shishu soshiki kansaibo kara mita mansei shishuen soshiki hakai to soshiki rimoderingu kijo no kaimei
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Elucidation of chronic periodontitis tissue destruction and tissue remodeling mechanism as seen from the periodontal tissue stem cells
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中川, 種昭
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ナカガワ, タネアキ
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Nakagawa, Taneaki
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慶應義塾大学・医学部・教授
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Research team head
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科研費研究者番号 : 00227745
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森川, 暁
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モリカワ, サトル
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Morikawa, Satoru
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慶應義塾大学・医学部・助教
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Research team member
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科研費研究者番号 : 00424169
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2015
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科学研究費補助金研究成果報告書
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2014
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歯周組織の恒常性は局所の歯根膜細胞や歯槽骨細胞によってなされているが, 移動してきた幹細胞様細胞が歯周組織の修復と再生に寄与している可能性があることが報告された。これらの細胞は骨髄間葉系幹細胞のマーカー(PDGFRa)を発現していた。歯周組織は発生学的に神経堤細胞にその起源を持つことからiPS細胞から神経堤細胞に誘導し, 歯および歯周組織再生療法へつなげることを本研究課題の目標とし, 以下の成果を得た。(1) ヒトiPSからの神経堤細胞誘導方法の確立。(2) 誘導した神経堤細胞由来間葉系幹細胞の増殖能と骨・軟骨・脂肪・末梢神経系への分化能の確認。(3) 誘導した幹細胞が遊走能を有していることが確認できた。
Homeostasis of periodontal tissue have been made by local periodontal ligament cells and alveolar bone cells. It has been reported that stem cell-like cells from the trunk migrate to periodontal tissue, and contributes to the regeneration and repair of periodontal tissue. Furthermore, these cells express the specific marker (PDGFRa) of bone marrow mesenchymal stem cells. Mesenchymal stem cells present in the periodontal tissue. The developmental origin of periodontal tissue is neural crest cells. We tried to induce neural crest cells from human iPS cells. It is the goal of this study aims to connect to periodontal tissue regeneration therapy , and obtained the following results. (1) We succeeded establishment of a method to generate human iPS cells derived human neural crest cells. (2) We conformed induced neural crest cells differentiated into osteo, chondro, fat, and peripheral nerve cells. (3) We verified that induced neural crest cells have highest migration potency.
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研究種目 : 基盤研究(C)
研究期間 : 2012～2014
課題番号 : 24592965
研究分野 : 歯周病学
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